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Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: A matched cohort study
Background and Objectives To evaluate the risk of coronary heart disease (CHD) associated with metabolic syndrome (MetS) and its individual components in a representative sample of diabetic and nondiabetic Iranians. Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts...
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| Published in: | Journal of clinical lipidology 2014-05, Vol.8 (3), p.279-286 |
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| container_end_page | 286 |
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| container_start_page | 279 |
| container_title | Journal of clinical lipidology |
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| creator | Esteghamati, Alireza, MD Hafezi-Nejad, Nima, MPH, MD Sheikhbahaei, Sara, MPH, MD Heidari, Behnam, MPH, MD Zandieh, Ali, MPH, MD Ebadi, Maryam, MD Nakhjavani, Manouchehr, MD |
| description | Background and Objectives To evaluate the risk of coronary heart disease (CHD) associated with metabolic syndrome (MetS) and its individual components in a representative sample of diabetic and nondiabetic Iranians. Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts consisting of 1737 nondiabetic and 2385 diabetic participants were followed for the first CHD event during 8.5 years (until December 2013). Results MetS is defined as having 3 individual components associated with increased risk of CHD (hazard ratio [HR] for MetS: in the unadjusted were 2.85 [2.27–3.57] and in the fully adjusted model 1.80 [1.42–2.28]). MetS was associated with lower hazard of CHD in subjects older than 65 (HR: 1.50 vs. 3.47; P for interaction < .05) and in men (HR: 1.68 vs. 4.87; P for interaction |
| doi_str_mv | 10.1016/j.jacl.2014.02.002 |
| format | article |
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Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts consisting of 1737 nondiabetic and 2385 diabetic participants were followed for the first CHD event during 8.5 years (until December 2013). Results MetS is defined as having 3 individual components associated with increased risk of CHD (hazard ratio [HR] for MetS: in the unadjusted were 2.85 [2.27–3.57] and in the fully adjusted model 1.80 [1.42–2.28]). MetS was associated with lower hazard of CHD in subjects older than 65 (HR: 1.50 vs. 3.47; P for interaction < .05) and in men (HR: 1.68 vs. 4.87; P for interaction < .05). Presence of 4 of 5 individual MetS components increased the risk of CHD associated with MetS as a constellation. The value of MetS is augmented in the presence of low high-density lipoprotein-cholesterol (HR: 5.74 [2.52–13.08]) versus its absence (HR 1.91 [1.33–2.75]), high triglycerides (HR: 3.39 [1.38–8.34] vs. 1.99 [1.40–2.82] in its absence) and elevated blood pressure (HR: 2.61 [1.43–4.76] vs. 1.80 [1.26–2.58] in its absence). Conclusions We address the value of MetS components in the prediction of CHD and in the absence of traditional risk factors. This study provides evidence for the synergistic effect of MetS components on the incidence of CHD.</description><identifier>ISSN: 1933-2874</identifier><identifier>EISSN: 1876-4789</identifier><identifier>DOI: 10.1016/j.jacl.2014.02.002</identifier><identifier>PMID: 24793349</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Cardiovascular ; Cholesterol - metabolism ; Cohort ; Cohort Studies ; Coronary Disease - epidemiology ; Coronary heart disease ; Diabetes Complications - epidemiology ; Epidemiology ; Female ; Follow-Up Studies ; Humans ; Hypertension ; Hypertriglyceridemia ; Incidence ; Iran ; Lipoproteins, HDL - metabolism ; Low HDL-C ; Male ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - epidemiology ; Middle Aged ; Risk Factors ; Sex Factors ; Triglycerides - metabolism</subject><ispartof>Journal of clinical lipidology, 2014-05, Vol.8 (3), p.279-286</ispartof><rights>National Lipid Association</rights><rights>2014 National Lipid Association</rights><rights>Copyright © 2014 National Lipid Association. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-94c1063002d25a24127d7cf340398d07938c043c6d18bc13e00600b0fff781033</citedby><cites>FETCH-LOGICAL-c411t-94c1063002d25a24127d7cf340398d07938c043c6d18bc13e00600b0fff781033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24793349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esteghamati, Alireza, MD</creatorcontrib><creatorcontrib>Hafezi-Nejad, Nima, MPH, MD</creatorcontrib><creatorcontrib>Sheikhbahaei, Sara, MPH, MD</creatorcontrib><creatorcontrib>Heidari, Behnam, MPH, MD</creatorcontrib><creatorcontrib>Zandieh, Ali, MPH, MD</creatorcontrib><creatorcontrib>Ebadi, Maryam, MD</creatorcontrib><creatorcontrib>Nakhjavani, Manouchehr, MD</creatorcontrib><title>Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: A matched cohort study</title><title>Journal of clinical lipidology</title><addtitle>J Clin Lipidol</addtitle><description>Background and Objectives To evaluate the risk of coronary heart disease (CHD) associated with metabolic syndrome (MetS) and its individual components in a representative sample of diabetic and nondiabetic Iranians. Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts consisting of 1737 nondiabetic and 2385 diabetic participants were followed for the first CHD event during 8.5 years (until December 2013). Results MetS is defined as having 3 individual components associated with increased risk of CHD (hazard ratio [HR] for MetS: in the unadjusted were 2.85 [2.27–3.57] and in the fully adjusted model 1.80 [1.42–2.28]). MetS was associated with lower hazard of CHD in subjects older than 65 (HR: 1.50 vs. 3.47; P for interaction < .05) and in men (HR: 1.68 vs. 4.87; P for interaction < .05). Presence of 4 of 5 individual MetS components increased the risk of CHD associated with MetS as a constellation. The value of MetS is augmented in the presence of low high-density lipoprotein-cholesterol (HR: 5.74 [2.52–13.08]) versus its absence (HR 1.91 [1.33–2.75]), high triglycerides (HR: 3.39 [1.38–8.34] vs. 1.99 [1.40–2.82] in its absence) and elevated blood pressure (HR: 2.61 [1.43–4.76] vs. 1.80 [1.26–2.58] in its absence). Conclusions We address the value of MetS components in the prediction of CHD and in the absence of traditional risk factors. This study provides evidence for the synergistic effect of MetS components on the incidence of CHD.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Cardiovascular</subject><subject>Cholesterol - metabolism</subject><subject>Cohort</subject><subject>Cohort Studies</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Diabetes Complications - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertriglyceridemia</subject><subject>Incidence</subject><subject>Iran</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>Low HDL-C</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Triglycerides - metabolism</subject><issn>1933-2874</issn><issn>1876-4789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9Ustu1TAUjBCIlsIPsEBeskk4fuQmQQipqnhUqoTEY2059omu08S--CRF9xv4aRxuYcGClS17ZuyZOUXxnEPFge9ejdVo7FQJ4KoCUQGIB8U5b5tdqZq2e5j3nZSlaBt1VjwhGgHquoH6cXEmVJOvVHde_Pzs6ZbFgdmYYjDpyPZo0sKcJzSEzBBF682Cjv3wy57NuJg-Tt4yOgaX4pwhwTG_EPPB-TvvVjNlsfkQA4bfp-w6meBNYLT2I9qFXrNLNpvF7rOojfuYn6NldcenxaPBTITP7teL4tv7d1-vPpY3nz5cX13elFZxvpSdshx2Mtt1ojZCcdG4xg5SgexaB9lZa0FJu3O87S2XCLAD6GEYhqblIOVF8fKke0jx-4q06NmTxWkyAeNKmteCSymbTmWoOEFtikQJB31Ifs4xaQ56K0GPeitBbyVoEDr_KpNe3Ouv_YzuL-VP6hnw5gTA7PLOY9JkPQaLzqcckHbR_1__7T90O_ngrZlu8Yg0xjWFnJ_mmjJBf9nGYJsCrgBA8Vr-Aghdrik</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Esteghamati, Alireza, MD</creator><creator>Hafezi-Nejad, Nima, MPH, MD</creator><creator>Sheikhbahaei, Sara, MPH, MD</creator><creator>Heidari, Behnam, MPH, MD</creator><creator>Zandieh, Ali, MPH, MD</creator><creator>Ebadi, Maryam, MD</creator><creator>Nakhjavani, Manouchehr, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: A matched cohort study</title><author>Esteghamati, Alireza, MD ; Hafezi-Nejad, Nima, MPH, MD ; Sheikhbahaei, Sara, MPH, MD ; Heidari, Behnam, MPH, MD ; Zandieh, Ali, MPH, MD ; Ebadi, Maryam, MD ; Nakhjavani, Manouchehr, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-94c1063002d25a24127d7cf340398d07938c043c6d18bc13e00600b0fff781033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Cardiovascular</topic><topic>Cholesterol - metabolism</topic><topic>Cohort</topic><topic>Cohort Studies</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary heart disease</topic><topic>Diabetes Complications - epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertriglyceridemia</topic><topic>Incidence</topic><topic>Iran</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>Low HDL-C</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esteghamati, Alireza, MD</creatorcontrib><creatorcontrib>Hafezi-Nejad, Nima, MPH, MD</creatorcontrib><creatorcontrib>Sheikhbahaei, Sara, MPH, MD</creatorcontrib><creatorcontrib>Heidari, Behnam, MPH, MD</creatorcontrib><creatorcontrib>Zandieh, Ali, MPH, MD</creatorcontrib><creatorcontrib>Ebadi, Maryam, MD</creatorcontrib><creatorcontrib>Nakhjavani, Manouchehr, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical lipidology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esteghamati, Alireza, MD</au><au>Hafezi-Nejad, Nima, MPH, MD</au><au>Sheikhbahaei, Sara, MPH, MD</au><au>Heidari, Behnam, MPH, MD</au><au>Zandieh, Ali, MPH, MD</au><au>Ebadi, Maryam, MD</au><au>Nakhjavani, Manouchehr, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: A matched cohort study</atitle><jtitle>Journal of clinical lipidology</jtitle><addtitle>J Clin Lipidol</addtitle><date>2014-05</date><risdate>2014</risdate><volume>8</volume><issue>3</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>1933-2874</issn><eissn>1876-4789</eissn><abstract>Background and Objectives To evaluate the risk of coronary heart disease (CHD) associated with metabolic syndrome (MetS) and its individual components in a representative sample of diabetic and nondiabetic Iranians. Moreover, we aimed to define the most hazardous MetS components. Methods Two cohorts consisting of 1737 nondiabetic and 2385 diabetic participants were followed for the first CHD event during 8.5 years (until December 2013). Results MetS is defined as having 3 individual components associated with increased risk of CHD (hazard ratio [HR] for MetS: in the unadjusted were 2.85 [2.27–3.57] and in the fully adjusted model 1.80 [1.42–2.28]). MetS was associated with lower hazard of CHD in subjects older than 65 (HR: 1.50 vs. 3.47; P for interaction < .05) and in men (HR: 1.68 vs. 4.87; P for interaction < .05). Presence of 4 of 5 individual MetS components increased the risk of CHD associated with MetS as a constellation. The value of MetS is augmented in the presence of low high-density lipoprotein-cholesterol (HR: 5.74 [2.52–13.08]) versus its absence (HR 1.91 [1.33–2.75]), high triglycerides (HR: 3.39 [1.38–8.34] vs. 1.99 [1.40–2.82] in its absence) and elevated blood pressure (HR: 2.61 [1.43–4.76] vs. 1.80 [1.26–2.58] in its absence). Conclusions We address the value of MetS components in the prediction of CHD and in the absence of traditional risk factors. This study provides evidence for the synergistic effect of MetS components on the incidence of CHD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24793349</pmid><doi>10.1016/j.jacl.2014.02.002</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of clinical lipidology, 2014-05, Vol.8 (3), p.279-286 |
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| subjects | Adult Age Factors Aged Cardiovascular Cholesterol - metabolism Cohort Cohort Studies Coronary Disease - epidemiology Coronary heart disease Diabetes Complications - epidemiology Epidemiology Female Follow-Up Studies Humans Hypertension Hypertriglyceridemia Incidence Iran Lipoproteins, HDL - metabolism Low HDL-C Male Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - epidemiology Middle Aged Risk Factors Sex Factors Triglycerides - metabolism |
| title | Risk of coronary heart disease associated with metabolic syndrome and its individual components in Iranian subjects: A matched cohort study |
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