Suboptimal glycaemic control enhances the risk of impaired prothrombotic state in youths with type 1 diabetes mellitus

Objective: To estimate markers of prothrombotic state and endothelial dysfunction in youths with type 1 diabetes mellitus (T1DM) and investigate possible associations with anthropometric/demographic data, glycaemic control and lipid profile. Methods: In a cross-sectional design, we recruited 155 you...

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Published in:Diabetes & vascular disease research 2014-05, Vol.11 (3), p.208-216
Main Authors: Kyrgios, Ioannis, Maggana, Ioanna, Giza, Styliani, Stergidou, Dorothea, Mouzaki, Konstantina, Kotanidou, Eleni P, Papadakis, Emmanouil, Galli-Tsinopoulou, Assimina
Format: Article
Language:English
Subjects:
Adolescent
Child
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Female
Fibrinogen - metabolism
Glycated Hemoglobin A - metabolism
Humans
Male
Plasminogen Activator Inhibitor 1 - blood
Thrombophilia - blood
Thrombophilia - complications
von Willebrand Factor - metabolism
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Summary:Objective: To estimate markers of prothrombotic state and endothelial dysfunction in youths with type 1 diabetes mellitus (T1DM) and investigate possible associations with anthropometric/demographic data, glycaemic control and lipid profile. Methods: In a cross-sectional design, we recruited 155 youths with T1DM and determined levels of plasminogen activator inhibitor-1-antigen (PAI-1-Ag), von Willebrand factor-antigen (vWF-Ag), fibrinogen (FB), lipids and glycosylated haemoglobin (HbA1c). Results: Of all the participants, 76 (49%) had increased levels of at least one of prothrombotic factors. Suboptimal glycaemic control was associated with a worse lipid profile and an eightfold increased risk of elevated vWF-Ag levels. Higher vWF-Ag concentrations were also correlated with impaired lipid profile and increased HbA1c values, whereas PAI-1-Ag was positively correlated only with triglyceride levels. After adjustment for potential confounders, only HbA1c contributed independently to the variation in vWF-Ag levels. Conclusion: Impaired prothrombotic state and consequently endothelial dysfunction are present in youths with T1DM, representing a cumulative risk factor for future cardiovascular disease (CVD). Achievement and maintenance of euglycaemia and normolipidaemia are crucial to decelerate progress of this process.
ISSN:1479-1641
1752-8984
DOI:10.1177/1479164114528821