Two New Rodent Models for Actinide Toxicity Studies

Two small rodent species, the grasshopper mouse (Onychomys leucogaster) and the deer mouse (Peromyscus maniculatus), have tenacious and high retention in the liver and skeleton of plutonium and americium following intraperitoneal injection of Pu and Am in citrate solution. Liver retention of Pu and...

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Bibliographic Details
Published in:Radiation research 1981-04, Vol.86 (1), p.115-122
Main Authors: Taylor, Glenn N., Jones, Craig W., Gardner, Paul A., Lloyd, Ray D., Mays, Charles W., Charrier, Keith E.
Format: Article
Language:English
Subjects:
Americium
Americium - metabolism
Americium - toxicity
Animal models
Animals
Animals, Laboratory
Body Burden
Cricetinae
Female
Hamsters
Liver
Male
Metabolism
Mice
Mice, Inbred Strains
Plutonium
Plutonium - metabolism
Plutonium - toxicity
Rats
Rodents
Skeleton
Time Factors
Tissue Distribution
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Summary:Two small rodent species, the grasshopper mouse (Onychomys leucogaster) and the deer mouse (Peromyscus maniculatus), have tenacious and high retention in the liver and skeleton of plutonium and americium following intraperitoneal injection of Pu and Am in citrate solution. Liver retention of Pu and Am in the grasshopper mouse is higher than liver retention in the deer mouse. Both of these rodents are relatively long-lived (median lifespans of approximately 1400 days) in comparison to common laboratory mice (Mus musculus), breed well in captivity, and adapt suitably to laboratory conditions. It is suggested that these two species of mice, in which plutonium retention is high and prolonged in both the skeleton and liver, as it is in man, may be useful animal models for actinide toxicity studies.
ISSN:0033-7587
1938-5404
DOI:10.2307/3575603