Distortion of the anterior part of the interhemispheric fissure: significance and implications for prenatal diagnosis

ABSTRACT In order to illustrate the significance of a new anatomical finding, distortion of the interhemispheric fissure (DIHF) associated with impacted medial borders of the frontal lobes, we report a retrospective observational study of 13 fetuses in which DIHF was identified on prenatal imaging....

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Published in:Ultrasound in obstetrics & gynecology 2014-03, Vol.43 (3), p.346-352
Main Authors: Vinurel, N., Van Nieuwenhuyse, A., Cagneaux, M., Garel, C., Quarello, E., Brasseur, M., Picone, O., Ferry, M., Gaucherand, P., des Portes, V., Guibaud, L.
Format: Article
Language:English
Subjects:
Cerebral Cortex - abnormalities
Cerebral Cortex - diagnostic imaging
Female
fetus
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
interhemispheric fissure
Magnetic Resonance Imaging
Malformations of Cortical Development - diagnostic imaging
Malformations of Cortical Development - embryology
Malformations of Cortical Development - pathology
midline
Predictive Value of Tests
Pregnancy
prenatal diagnosis
Retrospective Studies
Ultrasonography, Prenatal
ultrasound
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Summary:ABSTRACT In order to illustrate the significance of a new anatomical finding, distortion of the interhemispheric fissure (DIHF) associated with impacted medial borders of the frontal lobes, we report a retrospective observational study of 13 fetuses in which DIHF was identified on prenatal imaging. In 10 cases there were associated anatomical anomalies, including mainly midline anomalies (syntelencephaly (n = 2), lobar holoprosencephaly (n = 1), Aicardi syndrome (n = 2)), but also schizencephaly (n = 1), cortical dysplasia (n = 1) and more complex cerebral malformations (n = 3), including neural tube defect in two cases. Chromosomal anomaly was identified in two cases, including 6p deletion in a case without associated central nervous system anomalies and a complex mosaicism in one of the cases with syntelencephaly. In two cases, the finding was apparently isolated on both pre‐ and postnatal imaging, and the children were doing well at follow‐up, aged 4 and 5 years. The presence of DIHF on prenatal imaging may help in the diagnosis of cerebral anomalies, especially those involving the midline. If DIHF is apparently isolated on prenatal ultrasound, magnetic resonance imaging is recommended for careful analysis of gyration and midline, especially optic and olfactory structures. Karyotyping is also recommended. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.12498