Vitamin D status and the Cdx-2 polymorphism of the vitamin D receptor gene are determining factors of bone mineral density in young healthy postmenopausal women

▸ Vitamin D deficiency in postmenopausal women is a major public health problem. ▸ Moreover in an area with potential high availability of solar radiation. ▸ Age increased osteoporosis risk. ▸ BMI, reproductive years, high 25OHD and allele A Cdx-2 polymorphism are protective. Bone mineral density (B...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2013-07, Vol.136, p.187-189
Main Authors: Casado-Díaz, Antonio, Cuenca-Acevedo, Rafael, Navarro-Valverde, Cristina, Díaz-Molina, Carmen, Caballero-Villarraso, Javier, Santiago-Mora, Raquel, Dorado, Gabriel, Quesada-Gómez, José Manuel
Format: Article
Language:English
Subjects:
Adult
Aged
Bone Density - genetics
Bone Density - physiology
Bone mineral density
Cdx-2 polymorphism
CDX2 Transcription Factor
Cross-Sectional Studies
Female
Homeodomain Proteins - genetics
Humans
Middle Aged
Nutritional Status
Osteoporosis
Osteoporosis risk factor
Osteoporosis, Postmenopausal - genetics
Osteoporosis, Postmenopausal - metabolism
Polymorphism, Single Nucleotide - genetics
Postmenopause - genetics
Postmenopause - physiology
Receptors, Calcitriol - genetics
Spain - epidemiology
VDR
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin D Deficiency - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:▸ Vitamin D deficiency in postmenopausal women is a major public health problem. ▸ Moreover in an area with potential high availability of solar radiation. ▸ Age increased osteoporosis risk. ▸ BMI, reproductive years, high 25OHD and allele A Cdx-2 polymorphism are protective. Bone mineral density (BMD) is a main determinant of osteoporotic fractures. A cross-sectional study was conducted in 229 young, healthy postmenopausal women (PMW) to evaluate the contribution of the vitamin D endocrine system and other clinical, biochemical and genetic parameters. Clinical risk factors for osteoporosis were obtained by a questionnaire. Serum concentrations of 25OHD, 1,25(OH)2D, PTH, and bone turnover markers were measured. The BsmI, FokI and Cdx-2 polymorphisms of the vitamin D receptor (VDR) gene were determined. DXA and the WHO criteria were applied for the diagnosis of osteoporosis. Univariate logistic and multivariate logistic regression analyses were carried out. Results: The prevalence of vitamin D deficiency (
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2012.09.026