Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males

Purpose Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D 3 in healthy young males upon skeletal muscle function. Methods Participants ( n  = ...

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Bibliographic Details
Published in:European journal of applied physiology 2014-06, Vol.114 (6), p.1309-1320
Main Authors: Owens, Daniel J., Webber, Daniel, Impey, Samuel G., Tang, Jonathan, Donovan, Timothy F., Fraser, William D., Morton, James P., Close, Graeme L.
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Dietary Supplements
Double-Blind Method
Drug dosages
Exercise
Genomes
Human Physiology
Humans
Male
Muscle Contraction - drug effects
Muscle function
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Musculoskeletal system
Occupational Medicine/Industrial Medicine
Original Article
Parathyroid Hormone - blood
Physical fitness
Sports Medicine
Vitamin D
Vitamin D - administration & dosage
Vitamin D - blood
Vitamin D - pharmacology
Vitamins - administration & dosage
Vitamins - blood
Vitamins - pharmacology
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Summary:Purpose Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D 3 in healthy young males upon skeletal muscle function. Methods Participants ( n  = 29) received an oral dose of 10,000 IU day −1 vitamin D 3 (VITD) or a visually identical placebo (PLB) for 3 months. Serum 25[OH]D and intact parathyroid hormone (iPTH) were measured at baseline and at week 4, 8 and 12. Muscle function was assessed in n  = 22 participants by isokinetic dynamometry and percutaneous isometric electromyostimulation at baseline and at week 6 and 12. Results Baseline mean total serum 25[OH]D was 40 ± 17 and 41 ± 20 nmol L −1 for PLB and VITD, respectively. VITD showed a significant improvement in total 25[OH]D at week 4 (150 ± 31 nmol L −1 ) that remained elevated throughout the trial ( P   0.05). Conclusions Elevating total serum 25[OH]D to concentrations > 120 nmol L −1 has no effect on skeletal muscle function. We postulate that skeletal muscle function is only perturbed in conditions of severe deficiency (
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-014-2865-2