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Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males
Purpose Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D 3 in healthy young males upon skeletal muscle function. Methods Participants ( n = ...
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| Published in: | European journal of applied physiology 2014-06, Vol.114 (6), p.1309-1320 |
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| container_issue | 6 |
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| container_title | European journal of applied physiology |
| container_volume | 114 |
| creator | Owens, Daniel J. Webber, Daniel Impey, Samuel G. Tang, Jonathan Donovan, Timothy F. Fraser, William D. Morton, James P. Close, Graeme L. |
| description | Purpose
Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D
3
in healthy young males upon skeletal muscle function.
Methods
Participants (
n
= 29) received an oral dose of 10,000 IU day
−1
vitamin D
3
(VITD) or a visually identical placebo (PLB) for 3 months. Serum 25[OH]D and intact parathyroid hormone (iPTH) were measured at baseline and at week 4, 8 and 12. Muscle function was assessed in
n
= 22 participants by isokinetic dynamometry and percutaneous isometric electromyostimulation at baseline and at week 6 and 12.
Results
Baseline mean total serum 25[OH]D was 40 ± 17 and 41 ± 20 nmol L
−1
for PLB and VITD, respectively. VITD showed a significant improvement in total 25[OH]D at week 4 (150 ± 31 nmol L
−1
) that remained elevated throughout the trial (
P
0.05).
Conclusions
Elevating total serum 25[OH]D to concentrations > 120 nmol L
−1
has no effect on skeletal muscle function. We postulate that skeletal muscle function is only perturbed in conditions of severe deficiency ( |
| doi_str_mv | 10.1007/s00421-014-2865-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1524822410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1524822410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-851d9586269a16fbe7af2ad04065c6f3071a6b79d314527a3d88eb0839ae890f3</originalsourceid><addsrcrecordid>eNp1kU1rFjEURoMoba39AW4k4MbN2JtkJskspbVVKHSjbkPemTs1dZKM-Sj035vy1iJCV7mQ85x74SHkLYOPDECdZoCesw5Y33Eth46_IEesF2MnBVcvn2Y2HpLXOd8CgOZMH5BD3ksuQKojkn-4Yr0L9Jzmum0regzFFhcDnSNmGmKhzm8p3iH9Wb0NNP_CFYtdqa95WpFOMZRkp-La3LgNU3Et2JQu5LosbnJNSe9jDTfU2xXzG_JqsWvGk8f3mHy_-Pzt7Et3dX359ezTVTcJxUunBzaPg5ZcjpbJZYfKLtzO0IMcJrkIUMzKnRpnwfqBKytmrXEHWowW9QiLOCYf9t521u-KuRjv8oTragPGmg0beK857xk09P1_6G2sKbTrGiWFAqEH0Si2p6YUc064mC05b9O9YWAeGjH7RkxrxDw0YnjLvHs0153H-Snxt4IG8D2Q21e4wfTP6metfwBUHZdT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1563703853</pqid></control><display><type>article</type><title>Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males</title><source>Springer Nature</source><creator>Owens, Daniel J. ; Webber, Daniel ; Impey, Samuel G. ; Tang, Jonathan ; Donovan, Timothy F. ; Fraser, William D. ; Morton, James P. ; Close, Graeme L.</creator><creatorcontrib>Owens, Daniel J. ; Webber, Daniel ; Impey, Samuel G. ; Tang, Jonathan ; Donovan, Timothy F. ; Fraser, William D. ; Morton, James P. ; Close, Graeme L.</creatorcontrib><description>Purpose
Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D
3
in healthy young males upon skeletal muscle function.
Methods
Participants (
n
= 29) received an oral dose of 10,000 IU day
−1
vitamin D
3
(VITD) or a visually identical placebo (PLB) for 3 months. Serum 25[OH]D and intact parathyroid hormone (iPTH) were measured at baseline and at week 4, 8 and 12. Muscle function was assessed in
n
= 22 participants by isokinetic dynamometry and percutaneous isometric electromyostimulation at baseline and at week 6 and 12.
Results
Baseline mean total serum 25[OH]D was 40 ± 17 and 41 ± 20 nmol L
−1
for PLB and VITD, respectively. VITD showed a significant improvement in total 25[OH]D at week 4 (150 ± 31 nmol L
−1
) that remained elevated throughout the trial (
P
< 0.005). Contrastingly, PLB showed a significant decrease in 25[OH]D at week 12 (25 ± 15 nmol L
−1
) compared with baseline. Despite marked increases in total serum 25[OH]D in VITD and a decrease in PLB, there were no significant changes in any of the muscle function outcome measures at week 6 or 12 for either group (
P
> 0.05).
Conclusions
Elevating total serum 25[OH]D to concentrations > 120 nmol L
−1
has no effect on skeletal muscle function. We postulate that skeletal muscle function is only perturbed in conditions of severe deficiency (<12.5 nmol L
−1
).</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-014-2865-2</identifier><identifier>PMID: 24623067</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Biomedical and Life Sciences ; Biomedicine ; Dietary Supplements ; Double-Blind Method ; Drug dosages ; Exercise ; Genomes ; Human Physiology ; Humans ; Male ; Muscle Contraction - drug effects ; Muscle function ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiology ; Musculoskeletal system ; Occupational Medicine/Industrial Medicine ; Original Article ; Parathyroid Hormone - blood ; Physical fitness ; Sports Medicine ; Vitamin D ; Vitamin D - administration & dosage ; Vitamin D - blood ; Vitamin D - pharmacology ; Vitamins - administration & dosage ; Vitamins - blood ; Vitamins - pharmacology</subject><ispartof>European journal of applied physiology, 2014-06, Vol.114 (6), p.1309-1320</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-851d9586269a16fbe7af2ad04065c6f3071a6b79d314527a3d88eb0839ae890f3</citedby><cites>FETCH-LOGICAL-c372t-851d9586269a16fbe7af2ad04065c6f3071a6b79d314527a3d88eb0839ae890f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24623067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Owens, Daniel J.</creatorcontrib><creatorcontrib>Webber, Daniel</creatorcontrib><creatorcontrib>Impey, Samuel G.</creatorcontrib><creatorcontrib>Tang, Jonathan</creatorcontrib><creatorcontrib>Donovan, Timothy F.</creatorcontrib><creatorcontrib>Fraser, William D.</creatorcontrib><creatorcontrib>Morton, James P.</creatorcontrib><creatorcontrib>Close, Graeme L.</creatorcontrib><title>Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Purpose
Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D
3
in healthy young males upon skeletal muscle function.
Methods
Participants (
n
= 29) received an oral dose of 10,000 IU day
−1
vitamin D
3
(VITD) or a visually identical placebo (PLB) for 3 months. Serum 25[OH]D and intact parathyroid hormone (iPTH) were measured at baseline and at week 4, 8 and 12. Muscle function was assessed in
n
= 22 participants by isokinetic dynamometry and percutaneous isometric electromyostimulation at baseline and at week 6 and 12.
Results
Baseline mean total serum 25[OH]D was 40 ± 17 and 41 ± 20 nmol L
−1
for PLB and VITD, respectively. VITD showed a significant improvement in total 25[OH]D at week 4 (150 ± 31 nmol L
−1
) that remained elevated throughout the trial (
P
< 0.005). Contrastingly, PLB showed a significant decrease in 25[OH]D at week 12 (25 ± 15 nmol L
−1
) compared with baseline. Despite marked increases in total serum 25[OH]D in VITD and a decrease in PLB, there were no significant changes in any of the muscle function outcome measures at week 6 or 12 for either group (
P
> 0.05).
Conclusions
Elevating total serum 25[OH]D to concentrations > 120 nmol L
−1
has no effect on skeletal muscle function. We postulate that skeletal muscle function is only perturbed in conditions of severe deficiency (<12.5 nmol L
−1
).</description><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Drug dosages</subject><subject>Exercise</subject><subject>Genomes</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle function</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - physiology</subject><subject>Musculoskeletal system</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Parathyroid Hormone - blood</subject><subject>Physical fitness</subject><subject>Sports Medicine</subject><subject>Vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - pharmacology</subject><subject>Vitamins - administration & dosage</subject><subject>Vitamins - blood</subject><subject>Vitamins - pharmacology</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kU1rFjEURoMoba39AW4k4MbN2JtkJskspbVVKHSjbkPemTs1dZKM-Sj035vy1iJCV7mQ85x74SHkLYOPDECdZoCesw5Y33Eth46_IEesF2MnBVcvn2Y2HpLXOd8CgOZMH5BD3ksuQKojkn-4Yr0L9Jzmum0regzFFhcDnSNmGmKhzm8p3iH9Wb0NNP_CFYtdqa95WpFOMZRkp-La3LgNU3Et2JQu5LosbnJNSe9jDTfU2xXzG_JqsWvGk8f3mHy_-Pzt7Et3dX359ezTVTcJxUunBzaPg5ZcjpbJZYfKLtzO0IMcJrkIUMzKnRpnwfqBKytmrXEHWowW9QiLOCYf9t521u-KuRjv8oTragPGmg0beK857xk09P1_6G2sKbTrGiWFAqEH0Si2p6YUc064mC05b9O9YWAeGjH7RkxrxDw0YnjLvHs0153H-Snxt4IG8D2Q21e4wfTP6metfwBUHZdT</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Owens, Daniel J.</creator><creator>Webber, Daniel</creator><creator>Impey, Samuel G.</creator><creator>Tang, Jonathan</creator><creator>Donovan, Timothy F.</creator><creator>Fraser, William D.</creator><creator>Morton, James P.</creator><creator>Close, Graeme L.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males</title><author>Owens, Daniel J. ; Webber, Daniel ; Impey, Samuel G. ; Tang, Jonathan ; Donovan, Timothy F. ; Fraser, William D. ; Morton, James P. ; Close, Graeme L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-851d9586269a16fbe7af2ad04065c6f3071a6b79d314527a3d88eb0839ae890f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Drug dosages</topic><topic>Exercise</topic><topic>Genomes</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle function</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - physiology</topic><topic>Musculoskeletal system</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Parathyroid Hormone - blood</topic><topic>Physical fitness</topic><topic>Sports Medicine</topic><topic>Vitamin D</topic><topic>Vitamin D - administration & dosage</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - pharmacology</topic><topic>Vitamins - administration & dosage</topic><topic>Vitamins - blood</topic><topic>Vitamins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Owens, Daniel J.</creatorcontrib><creatorcontrib>Webber, Daniel</creatorcontrib><creatorcontrib>Impey, Samuel G.</creatorcontrib><creatorcontrib>Tang, Jonathan</creatorcontrib><creatorcontrib>Donovan, Timothy F.</creatorcontrib><creatorcontrib>Fraser, William D.</creatorcontrib><creatorcontrib>Morton, James P.</creatorcontrib><creatorcontrib>Close, Graeme L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owens, Daniel J.</au><au>Webber, Daniel</au><au>Impey, Samuel G.</au><au>Tang, Jonathan</au><au>Donovan, Timothy F.</au><au>Fraser, William D.</au><au>Morton, James P.</au><au>Close, Graeme L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>114</volume><issue>6</issue><spage>1309</spage><epage>1320</epage><pages>1309-1320</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Purpose
Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations. We aimed to assess the effect of oral vitamin D
3
in healthy young males upon skeletal muscle function.
Methods
Participants (
n
= 29) received an oral dose of 10,000 IU day
−1
vitamin D
3
(VITD) or a visually identical placebo (PLB) for 3 months. Serum 25[OH]D and intact parathyroid hormone (iPTH) were measured at baseline and at week 4, 8 and 12. Muscle function was assessed in
n
= 22 participants by isokinetic dynamometry and percutaneous isometric electromyostimulation at baseline and at week 6 and 12.
Results
Baseline mean total serum 25[OH]D was 40 ± 17 and 41 ± 20 nmol L
−1
for PLB and VITD, respectively. VITD showed a significant improvement in total 25[OH]D at week 4 (150 ± 31 nmol L
−1
) that remained elevated throughout the trial (
P
< 0.005). Contrastingly, PLB showed a significant decrease in 25[OH]D at week 12 (25 ± 15 nmol L
−1
) compared with baseline. Despite marked increases in total serum 25[OH]D in VITD and a decrease in PLB, there were no significant changes in any of the muscle function outcome measures at week 6 or 12 for either group (
P
> 0.05).
Conclusions
Elevating total serum 25[OH]D to concentrations > 120 nmol L
−1
has no effect on skeletal muscle function. We postulate that skeletal muscle function is only perturbed in conditions of severe deficiency (<12.5 nmol L
−1
).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24623067</pmid><doi>10.1007/s00421-014-2865-2</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2014-06, Vol.114 (6), p.1309-1320 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1524822410 |
| source | Springer Nature |
| subjects | Adult Biomedical and Life Sciences Biomedicine Dietary Supplements Double-Blind Method Drug dosages Exercise Genomes Human Physiology Humans Male Muscle Contraction - drug effects Muscle function Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Musculoskeletal system Occupational Medicine/Industrial Medicine Original Article Parathyroid Hormone - blood Physical fitness Sports Medicine Vitamin D Vitamin D - administration & dosage Vitamin D - blood Vitamin D - pharmacology Vitamins - administration & dosage Vitamins - blood Vitamins - pharmacology |
| title | Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males |
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