Evolution of Thyroid Function in Preterm Infants Detected by Screening for Congenital Hypothyroidism

Objective To determine the evolution of congenital hypothyroidism in preterms and the clinical features of permanent forms. Study design We retrospectively evaluated 24 preterm children detected by newborn screening for congenital hypothyroidism: first screening with blood-thyroid stimulating hormon...

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Bibliographic Details
Published in:The Journal of pediatrics 2014-06, Vol.164 (6), p.1296-1302
Main Authors: Vigone, Maria Cristina, MD, Caiulo, Silvana, MD, Di Frenna, Marianna, MD, Ghirardello, Stefano, MD, Corbetta, Carlo, MD, Mosca, Fabio, MD, Weber, Giovanna, MD
Format: Article
Language:English
Subjects:
Cohort Studies
Congenital Hypothyroidism - diagnosis
Congenital Hypothyroidism - drug therapy
Congenital Hypothyroidism - epidemiology
Female
Follow-Up Studies
Gestational Age
Humans
Incidence
Infant, Newborn
Infant, Premature
Male
Neonatal Screening - methods
Pediatrics
Retrospective Studies
Risk Assessment
Thyroid Function Tests
Thyrotropin - blood
Thyroxine - therapeutic use
Treatment Outcome
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Summary:Objective To determine the evolution of congenital hypothyroidism in preterms and the clinical features of permanent forms. Study design We retrospectively evaluated 24 preterm children detected by newborn screening for congenital hypothyroidism: first screening with blood-thyroid stimulating hormone cutoff ≥10 mU/L and second screening with blood-thyroid stimulating hormone cutoff ≥5 mU/L. After the age of 2 years, patients with eutopic thyroid had diagnostic reevaluations, including thyroid function testing and thyroid ultrasonography after L-thyroxine therapy withdrawal. Results The first screening identified 21.7% of patients with thyroid stimulating hormone elevation, and the second screening identified 73.9% of patients. One patient (4.4%) was identified with a third screening test; 21 patients had an eutopic thyroid and 3 patients a thyroid dysgenesis. At reevaluation, 5 patients (23.8%) showed permanent hypothyroidism (serum-thyroid stimulating hormone [s-TSH] >10 mU/L) resulting in the need to reintroduce therapy, 5 patients (23.8%) showed persistent hyperthyrotropinemia (s-TSH 5-10 mU/L), and 11 infants (52.4%) transient hypothyroidism (s-TSH
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2013.12.048