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The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading
Summary In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relatio...
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| Published in: | Clinical physiology and functional imaging 2014-05, Vol.34 (3), p.218-229 |
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| container_end_page | 229 |
| container_issue | 3 |
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| container_title | Clinical physiology and functional imaging |
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| creator | Weber, Tobias Ducos, Michel Mulder, Edwin Beijer, Åsa Herrera, Frankyn Zange, Jochen Degens, Hans Bloch, Wilhelm Rittweger, Jörn |
| description | Summary
In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relation to arterial blood flow and muscle perfusion. Eleven male subjects (31 ± 6 years) wore the HEPHAISTOS unloading orthosis unilaterally for 56 days. It allows habitual ambulation while greatly reducing plantar flexor activity and torque production. Endpoint measurements encompassed arterial blood flow, measured in the femoral artery using Doppler ultrasound, oxygenation of the soleus muscle assessed by near‐infrared spectroscopy, lactate concentrations determined in capillary blood and muscle activity using soleus muscle surface electromyography. Furthermore, soleus muscle biopsies were taken to investigate morphological muscle changes. After the intervention, maximal isokinetic torque was reduced by 23·4 ± 8·2% (P |
| doi_str_mv | 10.1111/cpf.12087 |
| format | article |
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In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relation to arterial blood flow and muscle perfusion. Eleven male subjects (31 ± 6 years) wore the HEPHAISTOS unloading orthosis unilaterally for 56 days. It allows habitual ambulation while greatly reducing plantar flexor activity and torque production. Endpoint measurements encompassed arterial blood flow, measured in the femoral artery using Doppler ultrasound, oxygenation of the soleus muscle assessed by near‐infrared spectroscopy, lactate concentrations determined in capillary blood and muscle activity using soleus muscle surface electromyography. Furthermore, soleus muscle biopsies were taken to investigate morphological muscle changes. After the intervention, maximal isokinetic torque was reduced by 23·4 ± 8·2% (P<0·001) and soleus fibre size was reduced by 8·5 ± 13% (P = 0·016). However, WoRPD remained unaffected as indicated by an unchanged loss of relative plantar flexor power between pre‐ and postexperiments (P = 0·88). Blood flow, tissue oxygenation, lactate concentrations and EMG median frequency kinematics during the exercise test were comparable before and after the intervention, whereas the increase of RMS in response to IIET was less following the intervention (P = 0·03). In conclusion, following submaximal isokinetic muscle work exercise‐induced muscle fatigue is unaffected after prolonged local muscle unloading. The observation that arterial blood flow was maintained may underlie the unchanged fatigability.</description><identifier>ISSN: 1475-0961</identifier><identifier>EISSN: 1475-097X</identifier><identifier>DOI: 10.1111/cpf.12087</identifier><identifier>PMID: 24119174</identifier><identifier>CODEN: CPFICA</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; arterial blood flow ; Biomechanical Phenomena ; Blood Flow Velocity ; Femoral Artery - diagnostic imaging ; Femoral Artery - physiopathology ; Humans ; Lactic Acid - blood ; Leg ; Male ; Muscle Contraction ; Muscle Fatigue ; muscle perfusion ; muscle power ; Muscle Strength ; muscle unloading ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - blood ; Muscular Atrophy - pathology ; Muscular Atrophy - physiopathology ; Orthotic Devices ; Regional Blood Flow ; Time Factors ; Torque ; Ultrasonography ; Weight-Bearing</subject><ispartof>Clinical physiology and functional imaging, 2014-05, Vol.34 (3), p.218-229</ispartof><rights>2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd</rights><rights>2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 Scandinavian Society of Clinical Physiology and Nuclear Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3397-7fb5d68304553a88ab2089e7e49613d0b2863557e558b44fa8c4481410de483</citedby><cites>FETCH-LOGICAL-c3397-7fb5d68304553a88ab2089e7e49613d0b2863557e558b44fa8c4481410de483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24119174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weber, Tobias</creatorcontrib><creatorcontrib>Ducos, Michel</creatorcontrib><creatorcontrib>Mulder, Edwin</creatorcontrib><creatorcontrib>Beijer, Åsa</creatorcontrib><creatorcontrib>Herrera, Frankyn</creatorcontrib><creatorcontrib>Zange, Jochen</creatorcontrib><creatorcontrib>Degens, Hans</creatorcontrib><creatorcontrib>Bloch, Wilhelm</creatorcontrib><creatorcontrib>Rittweger, Jörn</creatorcontrib><title>The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading</title><title>Clinical physiology and functional imaging</title><addtitle>Clin Physiol Funct Imaging</addtitle><description>Summary
In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relation to arterial blood flow and muscle perfusion. Eleven male subjects (31 ± 6 years) wore the HEPHAISTOS unloading orthosis unilaterally for 56 days. It allows habitual ambulation while greatly reducing plantar flexor activity and torque production. Endpoint measurements encompassed arterial blood flow, measured in the femoral artery using Doppler ultrasound, oxygenation of the soleus muscle assessed by near‐infrared spectroscopy, lactate concentrations determined in capillary blood and muscle activity using soleus muscle surface electromyography. Furthermore, soleus muscle biopsies were taken to investigate morphological muscle changes. After the intervention, maximal isokinetic torque was reduced by 23·4 ± 8·2% (P<0·001) and soleus fibre size was reduced by 8·5 ± 13% (P = 0·016). However, WoRPD remained unaffected as indicated by an unchanged loss of relative plantar flexor power between pre‐ and postexperiments (P = 0·88). Blood flow, tissue oxygenation, lactate concentrations and EMG median frequency kinematics during the exercise test were comparable before and after the intervention, whereas the increase of RMS in response to IIET was less following the intervention (P = 0·03). In conclusion, following submaximal isokinetic muscle work exercise‐induced muscle fatigue is unaffected after prolonged local muscle unloading. The observation that arterial blood flow was maintained may underlie the unchanged fatigability.</description><subject>Adult</subject><subject>arterial blood flow</subject><subject>Biomechanical Phenomena</subject><subject>Blood Flow Velocity</subject><subject>Femoral Artery - diagnostic imaging</subject><subject>Femoral Artery - physiopathology</subject><subject>Humans</subject><subject>Lactic Acid - blood</subject><subject>Leg</subject><subject>Male</subject><subject>Muscle Contraction</subject><subject>Muscle Fatigue</subject><subject>muscle perfusion</subject><subject>muscle power</subject><subject>Muscle Strength</subject><subject>muscle unloading</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Atrophy - blood</subject><subject>Muscular Atrophy - pathology</subject><subject>Muscular Atrophy - physiopathology</subject><subject>Orthotic Devices</subject><subject>Regional Blood Flow</subject><subject>Time Factors</subject><subject>Torque</subject><subject>Ultrasonography</subject><subject>Weight-Bearing</subject><issn>1475-0961</issn><issn>1475-097X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqN0UFu1DAUBmALgWgpLLgAssQGJNLasR07yzKiLVJbkKhKd5aTPLcunjjYiaZzA47BWThZPZ3pLJCQ8MZefO-3nn6EXlOyT_M5aAe7T0ui5BO0S7kUBanl1dPtu6I76EVKt4RQybh8jnZKTmlNJd9Fvy5uAEfwZnShTzduwA2MC4Aewx3E1iUoXN9NLXR4PqXWA7aZXk_wAZs4QnTG48aH0GHrwwKbfusGiHZKORUbmyEW1Z_fnVkm7EObhzZq6n0wneuvX6Jn1vgErzb3Hvp29OlidlKcfjn-PDs8LVrGallI24iuUoxwIZhRyjR57xok8Lwm60hTqooJIUEI1XBujWo5V5RT0gFXbA-9W6cOMfycII167lIL3psewpQ0FYzUSuSf_oPSUoi6Knmmb_-it2GKfV5jpagknKrV3-_Xqo0hpQhWD9HNTVxqSvSqR5171A89Zvtmkzg1c-i28rG4DA7WYOE8LP-dpGdfjx4ji_WESyPcbSdM_KEryaTQ38-PdXWmLi_P1Ud9xe4Bodq2yw</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Weber, Tobias</creator><creator>Ducos, Michel</creator><creator>Mulder, Edwin</creator><creator>Beijer, Åsa</creator><creator>Herrera, Frankyn</creator><creator>Zange, Jochen</creator><creator>Degens, Hans</creator><creator>Bloch, Wilhelm</creator><creator>Rittweger, Jörn</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7U5</scope><scope>8FD</scope><scope>K9.</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading</title><author>Weber, Tobias ; Ducos, Michel ; Mulder, Edwin ; Beijer, Åsa ; Herrera, Frankyn ; Zange, Jochen ; Degens, Hans ; Bloch, Wilhelm ; Rittweger, Jörn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3397-7fb5d68304553a88ab2089e7e49613d0b2863557e558b44fa8c4481410de483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>arterial blood flow</topic><topic>Biomechanical Phenomena</topic><topic>Blood Flow Velocity</topic><topic>Femoral Artery - diagnostic imaging</topic><topic>Femoral Artery - physiopathology</topic><topic>Humans</topic><topic>Lactic Acid - blood</topic><topic>Leg</topic><topic>Male</topic><topic>Muscle Contraction</topic><topic>Muscle Fatigue</topic><topic>muscle perfusion</topic><topic>muscle power</topic><topic>Muscle Strength</topic><topic>muscle unloading</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscular Atrophy - blood</topic><topic>Muscular Atrophy - pathology</topic><topic>Muscular Atrophy - physiopathology</topic><topic>Orthotic Devices</topic><topic>Regional Blood Flow</topic><topic>Time Factors</topic><topic>Torque</topic><topic>Ultrasonography</topic><topic>Weight-Bearing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weber, Tobias</creatorcontrib><creatorcontrib>Ducos, Michel</creatorcontrib><creatorcontrib>Mulder, Edwin</creatorcontrib><creatorcontrib>Beijer, Åsa</creatorcontrib><creatorcontrib>Herrera, Frankyn</creatorcontrib><creatorcontrib>Zange, Jochen</creatorcontrib><creatorcontrib>Degens, Hans</creatorcontrib><creatorcontrib>Bloch, Wilhelm</creatorcontrib><creatorcontrib>Rittweger, Jörn</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical physiology and functional imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weber, Tobias</au><au>Ducos, Michel</au><au>Mulder, Edwin</au><au>Beijer, Åsa</au><au>Herrera, Frankyn</au><au>Zange, Jochen</au><au>Degens, Hans</au><au>Bloch, Wilhelm</au><au>Rittweger, Jörn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading</atitle><jtitle>Clinical physiology and functional imaging</jtitle><addtitle>Clin Physiol Funct Imaging</addtitle><date>2014-05</date><risdate>2014</risdate><volume>34</volume><issue>3</issue><spage>218</spage><epage>229</epage><pages>218-229</pages><issn>1475-0961</issn><eissn>1475-097X</eissn><coden>CPFICA</coden><abstract>Summary
In the light of the dynamic nature of habitual plantar flexor activity, we utilized an incremental isokinetic exercise test (IIET) to assess the work‐related power deficit (WoRPD) as a measure for exercise‐induced muscle fatigue before and after prolonged calf muscle unloading and in relation to arterial blood flow and muscle perfusion. Eleven male subjects (31 ± 6 years) wore the HEPHAISTOS unloading orthosis unilaterally for 56 days. It allows habitual ambulation while greatly reducing plantar flexor activity and torque production. Endpoint measurements encompassed arterial blood flow, measured in the femoral artery using Doppler ultrasound, oxygenation of the soleus muscle assessed by near‐infrared spectroscopy, lactate concentrations determined in capillary blood and muscle activity using soleus muscle surface electromyography. Furthermore, soleus muscle biopsies were taken to investigate morphological muscle changes. After the intervention, maximal isokinetic torque was reduced by 23·4 ± 8·2% (P<0·001) and soleus fibre size was reduced by 8·5 ± 13% (P = 0·016). However, WoRPD remained unaffected as indicated by an unchanged loss of relative plantar flexor power between pre‐ and postexperiments (P = 0·88). Blood flow, tissue oxygenation, lactate concentrations and EMG median frequency kinematics during the exercise test were comparable before and after the intervention, whereas the increase of RMS in response to IIET was less following the intervention (P = 0·03). In conclusion, following submaximal isokinetic muscle work exercise‐induced muscle fatigue is unaffected after prolonged local muscle unloading. The observation that arterial blood flow was maintained may underlie the unchanged fatigability.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24119174</pmid><doi>10.1111/cpf.12087</doi><tpages>12</tpages></addata></record> |
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| ispartof | Clinical physiology and functional imaging, 2014-05, Vol.34 (3), p.218-229 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult arterial blood flow Biomechanical Phenomena Blood Flow Velocity Femoral Artery - diagnostic imaging Femoral Artery - physiopathology Humans Lactic Acid - blood Leg Male Muscle Contraction Muscle Fatigue muscle perfusion muscle power Muscle Strength muscle unloading Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscular Atrophy - blood Muscular Atrophy - pathology Muscular Atrophy - physiopathology Orthotic Devices Regional Blood Flow Time Factors Torque Ultrasonography Weight-Bearing |
| title | The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading |
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