Association between excess body weight and urine protein concentration in healthy dogs

Background Markedly overweight people can develop progressive proteinuria and kidney failure secondary to obesity‐related glomerulopathy (ORG). Glomerular lesions in dogs with experimentally induced obesity are similar to those in people with ORG. Objectives The aim of this study was to evaluate if...

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Published in:Veterinary clinical pathology 2014-06, Vol.43 (2), p.255-260
Main Authors: Tefft, Karen M., Shaw, Darcy H., Ihle, Sherri L., Burton, Shelley A., Pack, LeeAnn
Format: Article
Language:English
Subjects:
Albuminuria - veterinary
Animals
Body condition score
Body Weight
canine
Creatinine - urine
Dog Diseases - urine
Dogs
Female
Glomerulonephritis - urine
Glomerulonephritis - veterinary
Kidney Failure, Chronic - urine
Kidney Failure, Chronic - veterinary
Male
microalbuminuria
Obesity
Obesity - veterinary
obesity-related glomerulopathy
Proteins
Proteinuria - veterinary
Urinalysis - veterinary
Urine
urine protein:creatinine ratio
Weight control
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Summary:Background Markedly overweight people can develop progressive proteinuria and kidney failure secondary to obesity‐related glomerulopathy (ORG). Glomerular lesions in dogs with experimentally induced obesity are similar to those in people with ORG. Objectives The aim of this study was to evaluate if urine protein and albumin excretion is greater in overweight and obese dogs than in dogs of ideal body condition. Methods Client‐owned dogs were screened for underlying health conditions. These dogs were assigned a body condition score (BCS) using a 9‐point scoring system. Dogs with a BCS of ≥ 6 were classified as being overweight/obese, and dogs with a BCS of 4 or 5 were classified as being of ideal body weight. The urine protein:creatinine ratio (UPC) and urine albumin:creatinine ratio (UAC) were then determined, and compared between 20 overweight/obese dogs and 22 ideal body weight control dogs. Results Median UPC (0.04 [range, 0.01–0.14; interquartile range, 0.07]) and UAC (0.41 [0–10.39; 3.21]) of overweight/obese dogs were not significantly different from median UPC (0.04 [0.01–0.32; 0.07]) and UAC (0.18 [0–7.04; 1.75]) in ideal body weight dogs. Conclusions Clinicopathologic abnormalities consistent with ORG were absent from overweight/obese dogs in this study.
ISSN:0275-6382
1939-165X
DOI:10.1111/vcp.12139