Semisynthetic Cephalosporins. IV. Synthesis and Structure Activity Relationships of Parenterally Active 7-(4-(Substituted methyl)Phenyl)-Acetamido-3-Cephem-4-Carboxylic Acids

A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino- Delta -3-cephems to afford a family of parenterally active cephalosporins. A compound designated 13I had the broadest spectrum of activity and the highest potency of the group against both Gram-positive...

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Bibliographic Details
Published in:Journal of antibiotics 1981-01, Vol.34 (10), p.1311-1317
Main Authors: Nudelman, A, Haviv, F, Patchornick, A, Karoly-Haffly, E, Braun-Bucholts, F, Kaier, B, Itzchaki, J, Sasson, S, Erickson, R C
Format: Article
Language:English
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Summary:A group of novel 4-substituted phenylacetic acids were prepared and coupled with several 7-amino- Delta -3-cephems to afford a family of parenterally active cephalosporins. A compound designated 13I had the broadest spectrum of activity and the highest potency of the group against both Gram-positive and Gram-negative bacteria. The activity of 13I included high potency against penicillinase-producing ataphylococci and activity against anaerobes, including Bacteroides fragilis .
ISSN:0021-8820