Innate immune response to La Crosse virus infection

Viral encephalitis represents a significant, and costly, public health threat particularly for high-risk pediatric populations. An emerging mosquito-borne pathogen endemic to the United States, La Crosse virus (LACV) is one of the most common causes of viral encephalitis in children in the United St...

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Bibliographic Details
Published in:Journal of neurovirology 2014-04, Vol.20 (2), p.150-156
Main Authors: Taylor, Katherine G., Peterson, Karin E.
Format: Article
Language:English
Subjects:
Aedes - virology
Animals
Biomedical and Life Sciences
Biomedicine
Central Nervous System - immunology
Central Nervous System - pathology
Central Nervous System - virology
Child
Disease Reservoirs - veterinary
Disease Reservoirs - virology
Disease Susceptibility
Disease Vectors
Encephalitis, California - immunology
Encephalitis, California - pathology
Encephalitis, California - transmission
Encephalitis, California - virology
Host Specificity
Host-Pathogen Interactions
Humans
Immunity, Innate
Immunology
Infectious Diseases
Interferon Type I - biosynthesis
La Crosse virus
La Crosse virus - immunology
Mice
Neurology
Neurosciences
Review
Virology
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Summary:Viral encephalitis represents a significant, and costly, public health threat particularly for high-risk pediatric populations. An emerging mosquito-borne pathogen endemic to the United States, La Crosse virus (LACV) is one of the most common causes of viral encephalitis in children in the United States. However, no licensed therapeutics or vaccines currently exist for treatment. Hampering development efforts, the host response to LACV and its role in disease pathogenesis has only recently been examined. In this review, we discuss the current understanding of innate immune response in the context of viral pathogenesis and host susceptibility to LACV. In addition, we address the need for a clearer understanding of the early host–virus interactions in LACV infections as it relates to viral pathogenesis in the central nervous system.
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-013-0186-6