Placental alkaline phosphatase de-phosphorylates insulin-like growth factor (IGF)-binding protein-1

Abstract Background Insulin-like growth factors (IGF) regulate fetal growth through their effects on placenta. Their actions are influenced by IGF binding protein-1. Phosphorylated IGFBP-1 (pIGFBP-1) has high affinity for IGF-I and usually inhibits IGF-I activity but during pregnancy, it is de-phosp...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2014-07, Vol.35 (7), p.520-522
Main Authors: Solomon, A.L, Siddals, K.W, Baker, P.N, Gibson, J.M, Aplin, J.D, Westwood, M
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - metabolism
Biological and medical sciences
Embryology: invertebrates and vertebrates. Teratology
Female
Fetal Development
Fundamental and applied biological sciences. Psychology
GPI-Linked Proteins - metabolism
Humans
IGF
IGFBP-1
Insulin-Like Growth Factor Binding Protein 1 - chemistry
Insulin-Like Growth Factor Binding Protein 1 - metabolism
Insulin-Like Growth Factor I - metabolism
Internal Medicine
Isoenzymes - metabolism
Maternal
Maternal-Fetal Exchange
Obstetrics and Gynecology
Phosphorylation
Placenta - metabolism
PLAP
Pregnancy
Protein Isoforms - chemistry
Protein Isoforms - metabolism
Trophoblast
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Summary:Abstract Background Insulin-like growth factors (IGF) regulate fetal growth through their effects on placenta. Their actions are influenced by IGF binding protein-1. Phosphorylated IGFBP-1 (pIGFBP-1) has high affinity for IGF-I and usually inhibits IGF-I activity but during pregnancy, it is de-phosphorylated to generate lower affinity isoforms and consequently, increased IGF bioavailability. Here we investigate the role of placenta in this process. Results Our data show that term human placental explants, but not their conditioned medium, can de-phosphorylate IGFBP-1 through the action of placental alkaline phosphatase (PLAP). Discussion PLAP-mediated de-phosphorylation of IGFBP-1 may provide a mechanism for controlling IGF-I bioavailability and action at the maternal/fetal interface.
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2014.04.014