Evaluation of soluble CD14 subtype (presepsin) in burn sepsis

Abstract Background Diagnosing sepsis is difficult in burn patients because of the inflammatory mediators that alter postburn metabolic profile. Here, we compare a new marker presepsin with procalcitonin (PCT), c-reactive protein (CRP) and white blood cell (WBC) in diagnosis and follow up of sepsis...

Full description

Saved in:
Bibliographic Details
Published in:Burns 2014-06, Vol.40 (4), p.664-669
Main Authors: Çakır Madenci, Özlem, Yakupoğlu, Sezer, Benzonana, Nur, Yücel, Nihal, Akbaba, Derya, Orçun Kaptanağası, Asuman
Format: Article
Language:English
Subjects:
Adult
Burn sepsis
Burns - blood
Burns - complications
C-reactive protein
C-Reactive Protein - metabolism
Calcitonin - blood
Calcitonin Gene-Related Peptide
Cohort Studies
Critical Care
Diagnosis
Female
Humans
Leukocyte Count
Lipopolysaccharide Receptors - blood
Male
Middle Aged
Peptide Fragments - blood
Presepsin
Procalcitonin
Prospective Studies
Protein Precursors - blood
ROC Curve
Sepsis - blood
Sepsis - diagnosis
Sepsis - etiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Diagnosing sepsis is difficult in burn patients because of the inflammatory mediators that alter postburn metabolic profile. Here, we compare a new marker presepsin with procalcitonin (PCT), c-reactive protein (CRP) and white blood cell (WBC) in diagnosis and follow up of sepsis in burn patients. Methods Patients admitted to burn center of our institute were prospectively investigated. Presepsin, PCT, CRP and WBC levels were measured at admission and every 6 h for first day and daily thereafter. At all timing samples, patients were classified as sepsis or non-sepsis according to the current American Burn Association Consensus Criteria (ABA) 2007. Result 37 adult patients were evaluated. A total data of 611 time points were supplied. Sepsis time points differ significantly from non-sepsis in presepsin ( p < 0.0001), PCT ( p = 0.0012) and CRP ( p < 0.0001) levels. Non-surviving patient results differ significantly from survivors in presepsin ( p < 0.0001), PCT ( p = 0.0210) and CRP ( p = 0.0008). AUC-ROC % values for diagnosing sepsis were 83.4% for presepsin, 84.7% for PCT, 81.9% for CRP and 50.8% for WBC. Sepsis patients had significantly different presepsin, CRP and WBC but not PCT levels on their first day of sepsis compared to previous days. Conclusion Plasma presepsin levels have comparable performance in burn sepsis.
ISSN:0305-4179
1879-1409
DOI:10.1016/j.burns.2013.08.024