Accumulation of loading damage and unloading reperfusion injury — Modeling of the propagation of deep tissue ulcers

• Published in: Journal of biomechanics 2014-05, Vol.47 (7), p.1658-1664
• Main Authors: Xiao, Daniel Z.T, Wu, Shirley Y.Q, Mak, Arthur F.T
• Format: Article
• Language: English
• Subjects: Adipose Tissue - physiopathology; Biomechanics; Buttocks - injuries; Cushions; Damage; Damage accumulation; Deep tissue injury; Evolution; Finite Element Analysis; Humans; Injuries; Ischemia; Mathematical models; Models, Biological; Muscle damage; Muscle, Skeletal - physiopathology; Physical Medicine and Rehabilitation; Pressure ulcer; Pressure Ulcer - physiopathology; Pressure ulcers; Prominences; Rehabilitation engineering; Reperfusion Injury; Rodents; Stress, Mechanical; Studies; Ulcers; Wound Healing
• ISSN: 0021-9290; 1873-2380
• DOI: 10.1016/j.jbiomech.2014.02.036

Abstract Deep tissue injury (DTI) occurs in deep muscles around bony prominences due to excessive and prolonged mechanical loading acting on the skin surface. The condition is clinically challenging because it can escape being noticed till the damage propagates all the way to the skin. In this study, a semi-3D finite element model of a human buttock was used to simulate the process of ulcer evolution based on our recent damage accumulation and repair theory for DTI. The theory included not only the loading damage, but also further reperfusion and inflammatory injuries upon unloading. The results showed that depending on the model parameters and loading conditions, a deep tissue ulcer may initiate around a bony prominence and expand to affect the entire tissue thickness. The damage evolution can be affected by the tissue healing rate, the loading–unloading pattern and the cushion stiffness. The results may help clinical workers appreciate the importance of proper patient turning and the appropriate choice of cushion.