Enteral nutrition feeding alters antioxidant activity in unstimulated whole saliva composition of patients with neurological disorders

•The equilibrium oxidant/antioxidant is fundamental to maintain oral health.•Total saliva of patients with enteral nutrition shows alterations in antioxidant properties.•Patients with enteral nutrition are predisposed to oral disease triggered by oxidative stress. Patients with neurological disorder...

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Published in:Research in developmental disabilities 2014-06, Vol.35 (6), p.1209-1215
Main Authors: Cunha-Correia, Adriana Sales, Neto, Antonio Hernandes, Pereira, Ariana Ferreira, Aguiar, Sandra Maria Herondina Coelho Ávila, Nakamune, Ana Cláudia de Melo Stevanato
Format: Article
Language:English
Subjects:
Acids
Adolescent
Adult
Adult and adolescent clinical studies
Antioxidant activity
Antioxidants
Antioxidants - metabolism
Biological and medical sciences
Case-Control Studies
Deglutition Disorders - etiology
Deglutition Disorders - therapy
Enteral Nutrition
Female
Glutathione Peroxidase - metabolism
Humans
Intellectual deficiency
Male
Medical sciences
Middle Aged
Nervous System Diseases - complications
Neurological disorders
Neurology
Nutrition
Oral hygiene
Oxidative Stress
Paraplegia - complications
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Quadriplegia - complications
Saliva
Saliva - chemistry
Saliva - enzymology
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - analysis
Uric Acid - analysis
Young Adult
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Summary:•The equilibrium oxidant/antioxidant is fundamental to maintain oral health.•Total saliva of patients with enteral nutrition shows alterations in antioxidant properties.•Patients with enteral nutrition are predisposed to oral disease triggered by oxidative stress. Patients with neurological disorders have an increased risk of oral and systemic diseases due to compromised oral hygiene. If patients lose the ability to swallow and chew food as a result of their disorder, enteral nutrition is often utilized. However, this type of feeding may modify salivary antioxidant defenses, resulting in increased oxidative damage and the emergence of various diseases. The aim of this study was to evaluate the effects of enteral nutrition on biochemical parameters in the unstimulated whole saliva composition of patients with neurological disorders. For this, enzymatic (superoxide dismutase – SOD; glutathione peroxidase – GPx) and non-enzymatic (uric acid; ferric ion reducing antioxidant power – FRAP) antioxidant activity, as well as a marker for oxidative damage (thiobarbituric acid reactive substances – TBARS) were analyzed. Unstimulated whole saliva was collected from 12 patients with neurological disorders and tube-feeding (tube-fed group – TFG), 15 patients with neurological disorders and normal feeding via the mouth (non-tube-fed group – NTFG), and 12 volunteers without neurological disorders (control group – CG). The daily oral hygiene procedures of TFG and NTFG patients were similar and dental care was provided monthly by the same institution's dentist. All patients exhibited adequate oral health conditions. The salivary levels of FRAP, uric acid, SOD, GPx, TBARS, and total protein were compared between studied groups. FRAP was increased (p
ISSN:0891-4222
1873-3379
DOI:10.1016/j.ridd.2014.03.003