The reduced proportion of New splenic T-cells in the zinc-deficient growing rat is not due to increased susceptibility to apoptosis

Abstract Dietary zinc deficiency has been associated with an increased risk of infection. It has been reported that zinc-deficient rats have fewer New T-cells (TCRαβ+ CD90+ ) compared to diet-restricted and control rats, which over time could adversely affect the ability of the organism to fight off...

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Published in:Immunobiology (1979) 2014-08, Vol.219 (8), p.602-610
Main Authors: Blewett, Heather J, Mohankumar, Suresh K, Rech, Leslie, Rector, Edward S, Taylor, Carla G
Format: Article
Language:English
Subjects:
Advanced Basic Science
Allergy and Immunology
Animals
Apoptosis
CD90
Cell Separation
Cells, Cultured
Cytotoxicity, Immunologic
Dexamethasone - pharmacology
Feeding Behavior
Flow Cytometry
Rats
Rats, Sprague-Dawley
Spleen - pathology
T-Lymphocyte Subsets - drug effects
T-Lymphocyte Subsets - immunology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Thy-1 Antigens - metabolism
Zinc - deficiency
Zinc - immunology
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Summary:Abstract Dietary zinc deficiency has been associated with an increased risk of infection. It has been reported that zinc-deficient rats have fewer New T-cells (TCRαβ+ CD90+ ) compared to diet-restricted and control rats, which over time could adversely affect the ability of the organism to fight off infections. We hypothesized that the lower proportion of New T-cells in zinc deficiency is due to an increased susceptibility to apoptosis. Weanling, Sprague Dawley rats were assigned to one of four dietary treatment groups for 3 weeks: zinc-deficient (ZD,
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2014.03.001