Maintenance Cognitive-Behavioral Therapy and Manualized Psychoeducation in the Treatment of Recurrent Depression: A Multicenter Prospective Randomized Controlled Trial

ObjectiveThis multicenter study compared the relapse and recurrence outcomes of two active treatments, maintenance cognitive-behavioral therapy (CBT) and manualized psychoeducation, both in addition to treatment as usual, in patients in remission from depression.MethodThis was a multicenter prospect...

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Bibliographic Details
Published in:The American journal of psychiatry 2013-06, Vol.170 (6), p.624-632
Main Authors: Stangier, Ulrich, Hilling, Christine, Heidenreich, Thomas, Risch, Anne Katrin, Barocka, Arnd, Schlösser, Ralf, Kronfeld, Kai, Ruckes, Christian, Berger, Hartmut, Röschke, Joachim, Weck, Florian, Volk, Stephan, Hambrecht, Martin, Serfling, Richard, Erkwoh, Ralf, Stirn, Aglaja, Sobanski, Thomas, Hautzinger, Martin
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Antidepressive Agents - therapeutic use
Behavior therapy. Cognitive therapy
Biological and medical sciences
Cognitive therapy
Cognitive Therapy - methods
Combined Modality Therapy
Depression
Depressive Disorder, Major - therapy
Female
Humans
Male
Medical sciences
Mental depression
Middle Aged
Mood disorders
Patient Education as Topic - methods
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology
Psychopathology. Psychiatry
Secondary Prevention
Single-Blind Method
Treatment Outcome
Treatments
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Summary:ObjectiveThis multicenter study compared the relapse and recurrence outcomes of two active treatments, maintenance cognitive-behavioral therapy (CBT) and manualized psychoeducation, both in addition to treatment as usual, in patients in remission from depression.MethodThis was a multicenter prospective randomized observer-blinded study with two parallel groups. The authors assessed 180 patients with three or more previous major depressive episodes who met remission criteria over a 2-month baseline period and who were randomly assigned to 16 sessions of either maintenance CBT or manualized psychoeducation over 8 months and then followed up for 12 months. The main outcome measure was time to first relapse or recurrence of a major depression, based on DSM-IV criteria, as assessed by blinded observers with the Longitudinal Interval Follow-Up Evaluation.ResultsCox regression analysis showed that time to relapse or recurrence of major depression did not differ significantly between treatment conditions, but a significant interaction was observed between treatment condition and number of previous episodes (
ISSN:0002-953X
1535-7228
DOI:10.1176/appi.ajp.2013.12060734