Expression of Epstein-Barr Virus-encoded Latent Membrane Protein (LMP-1), p16 and p53 Proteins in Nonendemic Nasopharyngeal Carcinoma (NPC): A Clinicopathological Study

Background and Aims Although the latent membrane protein type 1 (LMP1) is frequently expressed in Epstein-Barr virus (EBV) malignancies, its contribution to the pathogenesis of nasopharyngeal carcinoma (NPC) is not fully defined. LMP1 functions as a viral mimic of the TNFR family member engaging a n...

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Published in:Archives of medical research 2014-04, Vol.45 (3), p.229-236
Main Authors: Rosales-Pérez, Samuel, Cano-Valdez, Ana M, Flores-Balcázar, Christian H, Guedea-Edo, Ferran, Lino-Silva, Leonardo S, Lozano-Borbalas, Alicia, Navarro-Martín, Arturo, Poitevin-Chacón, Adela
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma - metabolism
Carcinoma - pathology
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
EBV-LMP1
Epstein-Barr virus
Epstein-Barr Virus Infections - metabolism
Epstein-Barr Virus Infections - pathology
Female
Herpesvirus 4, Human - genetics
Humans
Immunohistochemistry
Internal Medicine
Kaplan-Meier Estimate
Male
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - metabolism
Nasopharyngeal Neoplasms - pathology
Neoplasm Recurrence, Local
p16
p53
Retrospective Studies
Sex Factors
Tumor Suppressor Protein p53 - metabolism
Viral Matrix Proteins - genetics
Viral Matrix Proteins - metabolism
Young Adult
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Summary:Background and Aims Although the latent membrane protein type 1 (LMP1) is frequently expressed in Epstein-Barr virus (EBV) malignancies, its contribution to the pathogenesis of nasopharyngeal carcinoma (NPC) is not fully defined. LMP1 functions as a viral mimic of the TNFR family member engaging a number of signaling pathways that induce morphological and phenotypic alterations. This study aimed to investigate the LMP1 expression and EBV infection in relation to clinical outcome and survival in a series of Mexican NPC patients. We also studied expression of p16 and p53 proteins. Methods We analyzed in 25 tumor specimens the expression of LMP1, p16 and p53 by immunohistochemistry (IHC) and EBV presence by IHC/in situ hybridization. Differences in clinical outcome and survival in relation to protein expression were correlated through χ2 statistics and Kaplan-Meier survival curves. Results Our results showed a rate of 92% (23/25) of EBV infection. The expressions of LMP-1, p16 and p53 proteins were 40.0, 44.0 and 40.0%, respectively. LMP-1 immunoexpression was more common in older patients (>50 vs.
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2014.02.002