Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting

The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closantel is also a known protonophore, we perfor...

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Bibliographic Details
Published in:	Journal of medicinal chemistry 2014-07, Vol.57 (13), p.5792-5799
Main Authors:	Gooyit, Major, Tricoche, Nancy, Lustigman, Sara, Janda, Kim D
Format:	Article
Language:	English
Subjects:	Animals Antinematodal Agents - therapeutic use Caenorhabditis elegans - metabolism Chitinases - antagonists & inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Enzyme Inhibitors - therapeutic use Ionophores - therapeutic use Molting - drug effects Onchocerca volvulus - drug effects Onchocerca volvulus - growth & development Onchocerciasis - drug therapy Salicylanilides - chemistry Salicylanilides - therapeutic use Structure-Activity Relationship Uncoupling Agents - therapeutic use
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