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Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma
Aim Microvascular invasion (MVI) is an important risk factor for early recurrence of hepatocellular carcinoma (HCC), but preoperative prediction of MVI is difficult. Methods A retrospective review was undertaken on 167 patients with primary solitary HCC who underwent initial hepatectomy. Independent...
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| Published in: | Hepatology research 2014-08, Vol.44 (8), p.846-853 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
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| container_end_page | 853 |
| container_issue | 8 |
| container_start_page | 846 |
| container_title | Hepatology research |
| container_volume | 44 |
| creator | Hirokawa, Fumitoshi Hayashi, Michihiro Miyamoto, Yoshiharu Asakuma, Mitsuhiro Shimizu, Tetsunosuke Komeda, Koji Inoue, Yoshihiro Uchiyama, Kazuhisa |
| description | Aim
Microvascular invasion (MVI) is an important risk factor for early recurrence of hepatocellular carcinoma (HCC), but preoperative prediction of MVI is difficult.
Methods
A retrospective review was undertaken on 167 patients with primary solitary HCC who underwent initial hepatectomy. Independent predictors of MVI were identified, and factors affecting disease‐free survival in patients with MVI were clarified.
Results
Of the 167 patients, 20 patients (12%) had MVI. Recurrence rates of HCC after hepatectomy in MVI patients were significantly worse than in patients without MVI (P |
| doi_str_mv | 10.1111/hepr.12196 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1548195319</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1548195319</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5276-256e9301d1ddc880e001b0a2f47ff9735c626d7c216778e17702f8e21b5cd96d3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0Eorw2fADKEiGl-JHYyRJVpUWqCkK8dpZrO8KQxMFOgP49DildMpsZyWeu71wAThEco1CXr7pxY4RRTnfAAcoYjiFJXnbDTDIaU5LQETj0_g1CxCBO9sEIk4wkmOUH4Om2a6WttI9EraLGaWVka52PbBFVRjr7KbzsSuEiU4fR2Lp_8bY0rXDrKHwtWit1Wf4yUjhpaluJY7BXiNLrk00_Ao_X04fJPF7czm4mV4tYppjRGKdU5wQihZSSWQZ1sLiCAhcJK4qckVRSTBWTGFHGMo1Y8F9kGqNVKlVOFTkC54Nu4-xHp33LK-N7O6LWtvMcpUmG8pSgPKAXAxqO8t7pgjfOVOEIjiDvc-R9jvw3xwCfbXS7VaXVFv0LLgBoAL5Mqdf_SPH59O7-TzQedoxv9fd2R7h3ThlhKX9ezvgDxSzBT0v-TH4AhPmNkg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1548195319</pqid></control><display><type>article</type><title>Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Hirokawa, Fumitoshi ; Hayashi, Michihiro ; Miyamoto, Yoshiharu ; Asakuma, Mitsuhiro ; Shimizu, Tetsunosuke ; Komeda, Koji ; Inoue, Yoshihiro ; Uchiyama, Kazuhisa</creator><creatorcontrib>Hirokawa, Fumitoshi ; Hayashi, Michihiro ; Miyamoto, Yoshiharu ; Asakuma, Mitsuhiro ; Shimizu, Tetsunosuke ; Komeda, Koji ; Inoue, Yoshihiro ; Uchiyama, Kazuhisa</creatorcontrib><description>Aim
Microvascular invasion (MVI) is an important risk factor for early recurrence of hepatocellular carcinoma (HCC), but preoperative prediction of MVI is difficult.
Methods
A retrospective review was undertaken on 167 patients with primary solitary HCC who underwent initial hepatectomy. Independent predictors of MVI were identified, and factors affecting disease‐free survival in patients with MVI were clarified.
Results
Of the 167 patients, 20 patients (12%) had MVI. Recurrence rates of HCC after hepatectomy in MVI patients were significantly worse than in patients without MVI (P < 0.0361). Univariate analysis revealed that positive L3‐AFP, PIVKA‐II ≥ 150 mAU/mL and tumor size ≥3 cm preoperatively were associated with positive MVI. On multivariate analysis, independent predictors of MVI were PIVKA‐II ≥ 150 mAU/mL (odds ratio [OR], 5.19; 95% confidence interval [95% CI], 1.44–24.87; P = 0.0109) and positive L3‐AFP (OR, 3.47; 95% CI, 1.19–10.75; P = 0.0229). Among the MVI‐positive group, the 1‐, 2‐ and 3‐year disease‐free survival rates were 78%, 58%, and 58% in patients with surgical margin (SM) ≥ 10 mm and 38%, 29%, and 29% in those with SM < 10 mm, respectively (P = 0.0263).
Conclusions
Patients with PIVKA‐II ≥ 150 mAU/mL and positive L3‐AFP on preoperative examination are at high risk for MVI.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.12196</identifier><identifier>PMID: 23834279</identifier><language>eng</language><publisher>Netherlands: Blackwell Publishing Ltd</publisher><subject>AFP-L3 ; HCC ; microvascular invasion ; PIVKA-II</subject><ispartof>Hepatology research, 2014-08, Vol.44 (8), p.846-853</ispartof><rights>2013 The Japan Society of Hepatology</rights><rights>2013 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5276-256e9301d1ddc880e001b0a2f47ff9735c626d7c216778e17702f8e21b5cd96d3</citedby><cites>FETCH-LOGICAL-c5276-256e9301d1ddc880e001b0a2f47ff9735c626d7c216778e17702f8e21b5cd96d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23834279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirokawa, Fumitoshi</creatorcontrib><creatorcontrib>Hayashi, Michihiro</creatorcontrib><creatorcontrib>Miyamoto, Yoshiharu</creatorcontrib><creatorcontrib>Asakuma, Mitsuhiro</creatorcontrib><creatorcontrib>Shimizu, Tetsunosuke</creatorcontrib><creatorcontrib>Komeda, Koji</creatorcontrib><creatorcontrib>Inoue, Yoshihiro</creatorcontrib><creatorcontrib>Uchiyama, Kazuhisa</creatorcontrib><title>Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim
Microvascular invasion (MVI) is an important risk factor for early recurrence of hepatocellular carcinoma (HCC), but preoperative prediction of MVI is difficult.
Methods
A retrospective review was undertaken on 167 patients with primary solitary HCC who underwent initial hepatectomy. Independent predictors of MVI were identified, and factors affecting disease‐free survival in patients with MVI were clarified.
Results
Of the 167 patients, 20 patients (12%) had MVI. Recurrence rates of HCC after hepatectomy in MVI patients were significantly worse than in patients without MVI (P < 0.0361). Univariate analysis revealed that positive L3‐AFP, PIVKA‐II ≥ 150 mAU/mL and tumor size ≥3 cm preoperatively were associated with positive MVI. On multivariate analysis, independent predictors of MVI were PIVKA‐II ≥ 150 mAU/mL (odds ratio [OR], 5.19; 95% confidence interval [95% CI], 1.44–24.87; P = 0.0109) and positive L3‐AFP (OR, 3.47; 95% CI, 1.19–10.75; P = 0.0229). Among the MVI‐positive group, the 1‐, 2‐ and 3‐year disease‐free survival rates were 78%, 58%, and 58% in patients with surgical margin (SM) ≥ 10 mm and 38%, 29%, and 29% in those with SM < 10 mm, respectively (P = 0.0263).
Conclusions
Patients with PIVKA‐II ≥ 150 mAU/mL and positive L3‐AFP on preoperative examination are at high risk for MVI.</description><subject>AFP-L3</subject><subject>HCC</subject><subject>microvascular invasion</subject><subject>PIVKA-II</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0Eorw2fADKEiGl-JHYyRJVpUWqCkK8dpZrO8KQxMFOgP49DildMpsZyWeu71wAThEco1CXr7pxY4RRTnfAAcoYjiFJXnbDTDIaU5LQETj0_g1CxCBO9sEIk4wkmOUH4Om2a6WttI9EraLGaWVka52PbBFVRjr7KbzsSuEiU4fR2Lp_8bY0rXDrKHwtWit1Wf4yUjhpaluJY7BXiNLrk00_Ao_X04fJPF7czm4mV4tYppjRGKdU5wQihZSSWQZ1sLiCAhcJK4qckVRSTBWTGFHGMo1Y8F9kGqNVKlVOFTkC54Nu4-xHp33LK-N7O6LWtvMcpUmG8pSgPKAXAxqO8t7pgjfOVOEIjiDvc-R9jvw3xwCfbXS7VaXVFv0LLgBoAL5Mqdf_SPH59O7-TzQedoxv9fd2R7h3ThlhKX9ezvgDxSzBT0v-TH4AhPmNkg</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Hirokawa, Fumitoshi</creator><creator>Hayashi, Michihiro</creator><creator>Miyamoto, Yoshiharu</creator><creator>Asakuma, Mitsuhiro</creator><creator>Shimizu, Tetsunosuke</creator><creator>Komeda, Koji</creator><creator>Inoue, Yoshihiro</creator><creator>Uchiyama, Kazuhisa</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201408</creationdate><title>Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma</title><author>Hirokawa, Fumitoshi ; Hayashi, Michihiro ; Miyamoto, Yoshiharu ; Asakuma, Mitsuhiro ; Shimizu, Tetsunosuke ; Komeda, Koji ; Inoue, Yoshihiro ; Uchiyama, Kazuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5276-256e9301d1ddc880e001b0a2f47ff9735c626d7c216778e17702f8e21b5cd96d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>AFP-L3</topic><topic>HCC</topic><topic>microvascular invasion</topic><topic>PIVKA-II</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirokawa, Fumitoshi</creatorcontrib><creatorcontrib>Hayashi, Michihiro</creatorcontrib><creatorcontrib>Miyamoto, Yoshiharu</creatorcontrib><creatorcontrib>Asakuma, Mitsuhiro</creatorcontrib><creatorcontrib>Shimizu, Tetsunosuke</creatorcontrib><creatorcontrib>Komeda, Koji</creatorcontrib><creatorcontrib>Inoue, Yoshihiro</creatorcontrib><creatorcontrib>Uchiyama, Kazuhisa</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirokawa, Fumitoshi</au><au>Hayashi, Michihiro</au><au>Miyamoto, Yoshiharu</au><au>Asakuma, Mitsuhiro</au><au>Shimizu, Tetsunosuke</au><au>Komeda, Koji</au><au>Inoue, Yoshihiro</au><au>Uchiyama, Kazuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2014-08</date><risdate>2014</risdate><volume>44</volume><issue>8</issue><spage>846</spage><epage>853</epage><pages>846-853</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
Microvascular invasion (MVI) is an important risk factor for early recurrence of hepatocellular carcinoma (HCC), but preoperative prediction of MVI is difficult.
Methods
A retrospective review was undertaken on 167 patients with primary solitary HCC who underwent initial hepatectomy. Independent predictors of MVI were identified, and factors affecting disease‐free survival in patients with MVI were clarified.
Results
Of the 167 patients, 20 patients (12%) had MVI. Recurrence rates of HCC after hepatectomy in MVI patients were significantly worse than in patients without MVI (P < 0.0361). Univariate analysis revealed that positive L3‐AFP, PIVKA‐II ≥ 150 mAU/mL and tumor size ≥3 cm preoperatively were associated with positive MVI. On multivariate analysis, independent predictors of MVI were PIVKA‐II ≥ 150 mAU/mL (odds ratio [OR], 5.19; 95% confidence interval [95% CI], 1.44–24.87; P = 0.0109) and positive L3‐AFP (OR, 3.47; 95% CI, 1.19–10.75; P = 0.0229). Among the MVI‐positive group, the 1‐, 2‐ and 3‐year disease‐free survival rates were 78%, 58%, and 58% in patients with surgical margin (SM) ≥ 10 mm and 38%, 29%, and 29% in those with SM < 10 mm, respectively (P = 0.0263).
Conclusions
Patients with PIVKA‐II ≥ 150 mAU/mL and positive L3‐AFP on preoperative examination are at high risk for MVI.</abstract><cop>Netherlands</cop><pub>Blackwell Publishing Ltd</pub><pmid>23834279</pmid><doi>10.1111/hepr.12196</doi><tpages>8</tpages></addata></record> |
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| ispartof | Hepatology research, 2014-08, Vol.44 (8), p.846-853 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | AFP-L3 HCC microvascular invasion PIVKA-II |
| title | Outcomes and predictors of microvascular invasion of solitary hepatocellular carcinoma |
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