Synthesis, Characterization, DNA Binding, Light Switch “On and Off”, Docking Studies and Cytotoxicity, of Ruthenium(II) and Cobalt(III) Polypyridyl Complexes

The novel ligand (dmbip) 2-(4-N, N-dimethylbenzenamine)1H-imidazo[4, 5-f][1, 10]phenanthroline and its complexes [Ru(phen) 2 dmbip] 2+ (1), [Ru(bpy) 2 dmbip] 2+ (2), [Co(phen) 2 dmbip] 3+ (3) and [Co(bpy) 2 dmbip] 3+ (4) [where phen = 1, 10-phenanthroline, bpy = 2, 2 ′ -bipyridine], have been synthe...

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Bibliographic Details
Published in:Journal of fluorescence 2014-05, Vol.24 (3), p.803-817
Main Authors: Reddy, M. Rajender, Reddy, Putta Venkat, Kumar, Yata Praveen, Srishailam, A., Nambigari, Navaneetha, Satyanarayana, S.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedicine
Biophysics
Biotechnology
Cell Survival - drug effects
Cobalt - chemistry
DNA - chemistry
DNA - metabolism
Intercalating Agents - chemistry
Light
Magnetic Resonance Spectroscopy
Neoplasms - drug therapy
Neoplasms - pathology
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Original Paper
Phenanthrolines - chemistry
Pyridines - chemistry
Ruthenium - chemistry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured
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Summary:The novel ligand (dmbip) 2-(4-N, N-dimethylbenzenamine)1H-imidazo[4, 5-f][1, 10]phenanthroline and its complexes [Ru(phen) 2 dmbip] 2+ (1), [Ru(bpy) 2 dmbip] 2+ (2), [Co(phen) 2 dmbip] 3+ (3) and [Co(bpy) 2 dmbip] 3+ (4) [where phen = 1, 10-phenanthroline, bpy = 2, 2 ′ -bipyridine], have been synthesized and characterized by elemental analysis, IR, UV-Vis, 1 H NMR, 13 C NMR and Mass spectra. The DNA binding properties of the complexes were investigated by absorption, emission, quenching studies, light switch “on and off”, salt dependent, sensor (cation and anion) studies, viscosity measurements, cyclic voltammetry, molecular modeling and docking studies. The four complexes were screened for Photo cleavage of pBR322 DNA, antimicrobial activity and cytotoxicity. The experimental results indicate that the four complexes can intercalate into DNA base pairs. The DNA-binding affinities of these complexes follow the order [Ru(phen) 2 dmbip] 2+ > [Co(phen) 2 dmbip] 3+ > [Ru(bpy) 2 dmbip] 2+ > [Co(bpy) 2 dmbip] 3+ .
ISSN:1053-0509
1573-4994
DOI:10.1007/s10895-014-1355-6