Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract

Early life exposure to adverse environments can lead to a variety of metabolic and cardiovascular diseases in offspring. We hypothesize that female reproductive function may also be affected, with subsequent implications for fertility. We used an established maternal low‐protein model where animals...

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Bibliographic Details
Published in:The FASEB journal 2013-10, Vol.27 (10), p.3959-3965
Main Authors: Aiken, Catherine E., Tarry‐Adkins, Jane L., Ozanne, Susan E.
Format: Article
Language:English
Subjects:
Animals
Anti-Mullerian Hormone - blood
Blood Glucose
Body Weight
developmental programming
Dietary Proteins - administration & dosage
Dietary Proteins - pharmacology
DNA Damage
DNA, Mitochondrial
Female
Maternal Nutritional Physiological Phenomena
mitochondrial DNA
Organ Size
Ovarian Follicle
Oviducts - metabolism
Oxidative Stress
Rats
Rats, Wistar
reproduction
senescence
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Summary:Early life exposure to adverse environments can lead to a variety of metabolic and cardiovascular diseases in offspring. We hypothesize that female reproductive function may also be affected, with subsequent implications for fertility. We used an established maternal low‐protein model where animals are born small but undergo rapid postnatal catch‐up growth by suckling a control‐fed dam (recuperated offspring). Markers of oxidative stress and cellular aging in reproductive tract tissues were assessed at 3 and 6 mo of age. Recuperated offspring had lower birth weight than controls (P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.13-234484