Quantitative impact of using different criteria for the laboratory diagnosis of type 1 von Willebrand disease

Summary Introduction Only ± 50% of patients with type 1 von Willebrand disease (VWD) have recognized molecular defects and diagnosis still rests on demonstrating low plasma von Willebrand factor (VWF) protein/function. However, no generalized consensus exists regarding the type and number of VWF var...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2014-08, Vol.12 (8), p.1238-1243
Main Authors: Quiroga, T., Goycoolea, M., Belmont, S., Panes, O., Aranda, E., Zúñiga, P., Pereira, J., Mezzano, D.
Format: Article
Language:English
Subjects:
Autoantigens - blood
blood coagulation disorders, inherited
Clinical Laboratory Techniques
diagnosis
hematologic tests
Humans
Medical research
Retrospective Studies
von Willebrand disease, type 1
von Willebrand Disease, Type 1 - blood
von Willebrand Disease, Type 1 - diagnosis
von Willebrand factor
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Summary:Summary Introduction Only ± 50% of patients with type 1 von Willebrand disease (VWD) have recognized molecular defects and diagnosis still rests on demonstrating low plasma von Willebrand factor (VWF) protein/function. However, no generalized consensus exists regarding the type and number of VWF variables that should be considered for diagnosis. Aim To compare the quantitative impact of four different criteria to diagnose type 1 VWD. Methods We tested four laboratory criteria on 4298 laboratory studies during a 5‐year period. The first was the National Heart, Lung, and Blood Institute recommendation, which diagnoses type 1 VWD with plasma VWF antigen (VWF:Ag) and VWF ristocetin cofactor (VWF:RCo)
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.12594