In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neonatal transection of infraorbital nerve upon primary and secondary trigeminal pathways in rats

Abstract Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensor...

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Bibliographic Details
Published in:Brain research 2014-09, Vol.1579, p.84-92
Main Authors: Ooi, Yasuhiro, Inui-Yamamoto, Chizuko, Suzuki, Takashi, Nakadate, Hiromichi, Nagase, Yoshitaka, Seiyama, Akitoshi, Yoshioka, Yoshichika, Seki, Junji
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Critical period
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Imaging
Male
Maxillary Nerve - injuries
Neonatal nerve transaction
Neural Pathways - pathology
Neurology
Rats
Rats, Wistar
Thalamus - pathology
Trigeminal Ganglion - pathology
Trigeminal Nerve - pathology
Trigeminal Nuclei - pathology
Trigeminal pathways
Ultra high-field T2-weighted MR imaging
Vertebrates: nervous system and sense organs
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Summary:Abstract Using 11.7 T ultra high-field T2-weighted MRI, the present study aimed to investigate pathological changes of primary and secondary trigeminal pathways following neonatal transection of infraorbital nerve in rats. The trigeminal pathways consist of spinal trigeminal tract, trigeminal sensory nuclear complex, medial lemniscus, ventromedial portion of external medullary lamina and ventral posterior nucleus of thalamus. By selecting optimum parameters of MRI such as repetition time, echo time, and slice orientation, this study visualized the trigeminal pathways in rats without any contrast agents. Pathological changes due to the nerve transection were found at 8 weeks of age as a marked reduction of the areas of the trigeminal pathways connecting from the injured nerve. In addition, T2-weighted MR images of the trigeminal nerve trunk and the spinal trigeminal tract suggest a communication of CSF through the trigeminal nerve between the inside and outside of the brain stem. These results support the utility of ultra high-field MRI system for noninvasive assessment of effects of trigeminal nerve injury upon the trigeminal pathways.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2014.07.013