The influence of glucose load on metabolism during minor surgery using remifentanil-induced anesthesia

Background During perioperative fasting, lipid metabolism gradually increases, resulting in free fatty acids (FFA) and/or ketone bodies. Suppression of surgical stress by remifentanil may allow the safe administration of glucose infusions, avoiding both hyperglycemia and ketogenesis. The effects of...

Full description

Saved in:
Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2014-09, Vol.58 (8), p.948-954
Main Authors: KAMBE, N., TANAKA, K., KAKUTA, N., KAWANISHI, R., TSUTSUMI, Y. M.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
Androstanols - adverse effects
Creatine - blood
Fatty Acids, Nonesterified - blood
Female
Glucose
Glucose - administration & dosage
Glucose - pharmacology
Humans
Hydrocortisone - blood
Hyperglycemia
Hyperglycemia - prevention & control
Infusions, Intravenous
Insulin - blood
Intraoperative Complications - blood
Intraoperative Complications - prevention & control
Ketone Bodies - blood
Lipid Metabolism
Male
Metabolism
Methylhistidines - blood
Middle Aged
Piperidines - adverse effects
Single-Blind Method
Surgery
Thiamylal - adverse effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background During perioperative fasting, lipid metabolism gradually increases, resulting in free fatty acids (FFA) and/or ketone bodies. Suppression of surgical stress by remifentanil may allow the safe administration of glucose infusions, avoiding both hyperglycemia and ketogenesis. The effects of glucose infusion on glucose and lipid metabolism were therefore investigated in patients undergoing minor surgery with remifentanil anesthesia. Methods Thirty‐four patients were randomized 1 : 1 to receive no glucose (0G group) or low‐dose glucose (0.1 g/kg/h for 1 h followed by 0.05 g/kg/h for 1 h; LG group). The concentrations of glucose, adrenocorticotropic hormone (ACTH), 3‐methylhistidine (3‐MH), insulin, cortisol, FFA, creatinine (Cr), and ketone bodies were measured before anesthetic induction, 1 and 2 h after glucose infusion, at the end of surgery, and the next morning. Results The concentrations of cortisol and ACTH decreased during surgery in both groups when compared with the concentrations before anesthesia and at the end of surgery (P 
ISSN:0001-5172
1399-6576
DOI:10.1111/aas.12335