Treatment plan comparison between stereotactic body radiation therapy techniques for prostate cancer: Non-isocentric CyberKnife versus isocentric RapidArc

Abstract Purpose The aim of this study was to evaluate the feasibility and dose distribution of two different stereotactic body radiation therapy (SBRT) techniques, isocentric RapidArc (RA) and non-isocentric CyberKnife (CK), for the treatment of localized prostate cancer. Methods Two groups of pati...

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Bibliographic Details
Published in:Physica medica 2014-09, Vol.30 (6), p.654-661
Main Authors: Lin, Yu-Wei, Lin, Kuei-Hua, Ho, Hsiu-Wen, Lin, Hsiu-Man, Lin, Li-Ching, Lee, Steve P, Chui, Chen-Shou
Format: Article
Language:English
Subjects:
CyberKnife
Humans
Male
Organ Sparing Treatments
Prostate cancer
Prostatic Neoplasms - radiotherapy
Prostatic Neoplasms - surgery
Radiology
Radiosurgery - adverse effects
Radiosurgery - methods
Radiotherapy Planning, Computer-Assisted - methods
RapidArc
Stereotactic body radiation therapy
Volumetric modulated arc therapy
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Summary:Abstract Purpose The aim of this study was to evaluate the feasibility and dose distribution of two different stereotactic body radiation therapy (SBRT) techniques, isocentric RapidArc (RA) and non-isocentric CyberKnife (CK), for the treatment of localized prostate cancer. Methods Two groups of patients (Groups 1 and 2 with ten patients per group) treated with CK were re-planned with RA. The patients were grouped according to the rectum constraint used (Group1, maximum dose for rectum; Group 2, dose–volume histogram for rectum). The prescription dose was 37.5 Gy in five fractions. The two SBRT techniques were compared by target coverage, normal tissue sparing, and dose distribution parameters. Monitor units (MUs) and the delivery time were likewise compared to assess delivery efficiency. Results The RA plans consistently exhibited superior PTV coverage and better rectum sparing at low doses in the both groups. The conformity and heterogeneity indices of the RA plans were better than the CK plans. Additionally, the RA plans resulted in fewer low-dose regions, lower MUs, and faster delivery times than the CK plans. Conclusions The good dosimetric distribution and shorter delivery time make RA an attractive SBRT technique for the treatment of localized prostate cancer.
ISSN:1120-1797
1724-191X
DOI:10.1016/j.ejmp.2014.03.008