Evaluation of safety and immunogenicity of a live attenuated tetravalent (G1–G4) Bovine-Human Reassortant Rotavirus vaccine (BRV-TV) in healthy Indian adults and infants

Highlights • No safety concerns were reported in adults or children with all doses of BRV tested. • All doses tested were immunogenic resulting in an increase in the anti-rotavirus IgA antibodies. • Increasing antigen concentration resulted in a greater proportion of seroconversion.

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Bibliographic Details
Published in:Vaccine 2014-08, Vol.32, p.A117-A123
Main Authors: Dhingra, M.S, Kundu, R, Gupta, M, Kanungo, S, Ganguly, N, Singh, M.P, Bhattacharya, M.K, Ghosh, R, Kumar, R, Sur, D, Chadha, S.M, Saluja, T
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Animals
Antibodies, Viral - blood
Cattle
Children & youth
Developing countries
Diarrhea
Double-Blind Method
Fatalities
Female
Gastroenteritis
Gastroenteritis - prevention & control
Gastroenteritis - virology
Healthy Volunteers
Human populations
Human rotavirus
Humans
Immune response
Immunogenicity
Immunoglobulin A - blood
Infant
Infants
LDCs
Male
Middle Aged
Prospective Studies
Public health
Reassortant Viruses
Rotavirus
Rotavirus Infections - prevention & control
Rotavirus vaccine
Rotavirus Vaccines - therapeutic use
Safety
Seroresponse
Single-Blind Method
Vaccines
Vaccines, Attenuated - therapeutic use
Virus Shedding
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Description
Summary:Highlights • No safety concerns were reported in adults or children with all doses of BRV tested. • All doses tested were immunogenic resulting in an increase in the anti-rotavirus IgA antibodies. • Increasing antigen concentration resulted in a greater proportion of seroconversion.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.03.069