Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

Maintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. However, data supporting this hypothesis are focused on the developmental potential of lymphocyte populations and are thus insufficient to establish the functional hallmarks of stemness. Here, we investigate...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Mass.), 2014-07, Vol.41 (1), p.116-126
Main Authors:	Graef, Patricia, Buchholz, Veit R., Stemberger, Christian, Flossdorf, Michael, Henkel, Lynette, Schiemann, Matthias, Drexler, Ingo, Höfer, Thomas, Riddell, Stanley R., Busch, Dirk H.
Format:	Article
Language:	English
Subjects:	Adult Stem Cells - immunology Animals Blood Bone marrow CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Differentiation - immunology Cell Lineage - immunology Experiments Immunocompetence - immunology Immunologic Memory - immunology Immunotherapy, Adoptive Infections L-Selectin - immunology Listeria Listeria monocytogenes - immunology Listeriosis - immunology Lymphocyte Activation - immunology Lymphocytes Mice Mice, Inbred C57BL Mice, Knockout Multipotent Stem Cells - immunology Statistical analysis Stem cells Studies T cell receptors T-Lymphocyte Subsets - immunology
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