Time-dependent change of blood flow in the prostate treated with high-intensity focused ultrasound

• Published in: International journal of urology 2014-09, Vol.21 (9), p.942-945
• Main Authors: Shoji, Sunao, Tonooka, Akiko, Hashimoto, Akio, Nakamoto, Masahiko, Tomonaga, Tetsuro, Nakano, Mayura, Sato, Haruhiro, Terachi, Toshiro, Koike, Junki, Uchida, Toyoaki
• Format: Article
• Language: English
• Subjects: blood flow; high-intensity focused ultrasound; High-Intensity Focused Ultrasound Ablation; Humans; Magnetic Resonance Imaging; Male; pathology; prostate cancer; Prostatic Neoplasms - blood supply; Prostatic Neoplasms - diagnostic imaging; Regional Blood Flow; Retrospective Studies; Time Factors; Ultrasonography
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/iju.12515

Avascular areas on contrast‐enhanced magnetic resonance imaging have been considered to be areas of localized prostate cancer successfully treated by high‐intensity focused ultrasound. However, the optimal timing of magnetic resonance imaging has not been discussed. The thermal effect of high‐intensity focused ultrasound is degraded by regional prostatic blood flow. Conversely, the mechanical effect of high‐intensity focused ultrasound (cavitation) is not affected by blood flow, and can induce vessel damage. In this series, the longitudinal change of blood flow on contrast‐enhanced magnetic resonance imaging was observed from postoperative day 1 to postoperative day 14 in 10 patients treated with high‐intensity focused ultrasound. The median rates of increase in the non‐enhanced volume of the whole gland, transition zone and peripheral zone from postoperative day 1 to postoperative day 14 were 36%, 39%, and 34%, respectively. In another pathological analysis of the prostate tissue of 17 patients immediately after high‐intensity focused ultrasound without neoadjuvant hormonal therapy, we observed diffuse coagulative degeneration and partial non‐coagulative prostate tissue around arteries with vascular endothelial cell detachment. These observations on contrast‐enhanced magnetic resonance imaging support a time‐dependent change of the blood flow in the prostate treated with high‐intensity focused ultrasound. Additionally, our pathological findings support the longitudinal changes of these magnetic resonance imaging findings. Further large‐scale studies will investigate the most appropriate timing of contrast‐enhanced magnetic resonance imaging for evaluation of the effectiveness of high‐intensity focused ultrasound for localized prostate cancer.