Decreased trunk fat and triglycerides after strength training are associated with reduced LPS levels in HIV-infected individuals

Microbial translocation has been proposed to contribute to cardiovascular risk in HIV-infected individuals. We have previously shown a strong association between visceral fat volumes, triglycerides and LPS levels in HIV-seronegative individuals, and that strength training reduces trunk fat and trigl...

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Bibliographic Details
Published in:Antiviral therapy 2013-01, Vol.18, p.A47-A47
Main Authors: Troseid, M, Pedersen, Klarlund Klarlund, Ditlevsen, S, Hviid, T, Gerstoft, J, Hansen, T Grondahl, Nielsen, S Dam, Lindegaard, B
Format: Article
Language:English
Subjects:
Human immunodeficiency virus
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Summary:Microbial translocation has been proposed to contribute to cardiovascular risk in HIV-infected individuals. We have previously shown a strong association between visceral fat volumes, triglycerides and LPS levels in HIV-seronegative individuals, and that strength training reduces trunk fat and triglycerides in HIV-infected individuals. We hypothesized that strength training would reduce LPS levels and that the reduction would be associated with a reduction in trunk fat and triglycerides. Although plasma levels of LPS were not reduced by the interventions, there was a significant association between reduced trunk fat mass, triglycerides and LPS levels after strength training. The direction of these associations should be explored in future studies. We propose that strategies to improve body composition and lipid profile may improve the cardiovascular risk profile in HIV-infection, in part by a reduction in LPS levels.
ISSN:1359-6535