Cognitive slowing in Parkinson's disease is related to frontostriatal dopaminergic dysfunction

Abstract Background Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex. Methods The authors evaluated the relationship betw...

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Bibliographic Details
Published in:Journal of the neurological sciences 2013-06, Vol.329 (1), p.23-28
Main Authors: Jokinen, Pekka, Karrasch, Mira, Brück, Anna, Johansson, Jarkko, Bergman, Jörgen, Rinne, Juha O
Format: Article
Language:English
Subjects:
Aged
Choice Behavior
Cognition
Cognition Disorders - etiology
Cognition Disorders - pathology
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dihydroxyphenylalanine - analogs & derivatives
Dopamine - metabolism
Fdopa
Female
Frontal Lobe - diagnostic imaging
Frontal Lobe - metabolism
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neurology
Neuropsychological Tests
Parkinson Disease - complications
Parkinson Disease - pathology
Parkinson's disease
PET
Positron-Emission Tomography
Reaction Time
Statistics, Nonparametric
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Summary:Abstract Background Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex. Methods The authors evaluated the relationship between frontostriatal dopaminergic function and cognitive performance, especially cognitive processing speed by performing [18 F]fluorodopa PET and computerized tests of automatic and controlled cognitive processing speed (CogniSpeed) in 23 newly diagnosed and unmedicated PD patients and 14 controls. Results PD patients were slower than the controls in all the CogniSpeed measures studied. The Fdopa uptake in caudate nucleus correlated negatively with slowing on all the tests. Slower performance in relatively automatic processes measured by choice reaction tasks as well as in more controlled processes measured by a calculation task was related to reduced Fdopa uptake in the anterior cingulate gyrus. The reduced dopaminergic function in the thalamus was associated with the slower performance in the subtraction test. Conclusion Our study indicates that dopaminergic dysfunction within neural networks linking striatum to prefrontal cortex is involved in the slowing of both automatic and controlled cognitive processing in PD patients.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2013.03.006