Loading…
Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue
Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.
Saved in:
| Published in: | Organic & biomolecular chemistry 2014-07, Vol.12 (28), p.5235-5242 |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33 |
| container_end_page | 5242 |
| container_issue | 28 |
| container_start_page | 5235 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 12 |
| creator | Scuotto, M Persico, M Bucci, M Vellecco, V Borbone, N Morelli, E Oliviero, G Novellino, E Piccialli, G Cirino, G Varra, M Fattorusso, C Mayol, L |
| description | Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure. |
| doi_str_mv | 10.1039/c4ob00149d |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1560115201</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1540713000</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33</originalsourceid><addsrcrecordid>eNqNkT1PwzAQhi0EolBY-AHII0IqnGPna4TyKVXqUubIsS_FKLGL7SB15o-T0tKZ6e5ePXqGewm5YHDDgJe3SrgagIlSH5ATJvJ8AikvD_d7AiNyGsLHwJR5Jo7JKBFlAolgJ-R73scQpdXGLik2DaoYqLNU2mjiu3ddbYZDRfNl4pq6hnZOm8agpov7O6qNDBE9ug59oMrZKI3dmKSlbhWNkm27pqve4-BYq9YoanvVootGD5GVrVv2eEaOGtkGPN_NMXl7elxMXyaz-fPr9G42UTyBOKkTyLAQhRRFiqzQIBqNKFNUXGiUKuEyUUWOPK2zXBQi4zVXNaQSS64LyfmYXG29K-8-ewyx6kxQ2LbSoutDxdIMGBvexf6BCsgZB4ABvd6iyrsQPDbVyptO-nXFoNr0U03F_P63n4cBvtx5-7pDvUf_CuE_sxuNpw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1540713000</pqid></control><display><type>article</type><title>Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue</title><source>Royal Society of Chemistry</source><creator>Scuotto, M ; Persico, M ; Bucci, M ; Vellecco, V ; Borbone, N ; Morelli, E ; Oliviero, G ; Novellino, E ; Piccialli, G ; Cirino, G ; Varra, M ; Fattorusso, C ; Mayol, L</creator><creatorcontrib>Scuotto, M ; Persico, M ; Bucci, M ; Vellecco, V ; Borbone, N ; Morelli, E ; Oliviero, G ; Novellino, E ; Piccialli, G ; Cirino, G ; Varra, M ; Fattorusso, C ; Mayol, L</creatorcontrib><description>Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/c4ob00149d</identifier><identifier>PMID: 24920241</identifier><language>eng</language><publisher>England</publisher><subject>Antithrombins - chemical synthesis ; Antithrombins - chemistry ; Aptamers, Nucleotide - chemical synthesis ; Aptamers, Nucleotide - chemistry ; Circular Dichroism ; G-Quadruplexes ; Models, Molecular ; Molecular Mimicry ; Nucleosides - chemistry ; Optical Rotation ; Stereoisomerism ; Thermodynamics ; Thrombin - antagonists & inhibitors ; Thrombin - chemistry</subject><ispartof>Organic & biomolecular chemistry, 2014-07, Vol.12 (28), p.5235-5242</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33</citedby><cites>FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24920241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scuotto, M</creatorcontrib><creatorcontrib>Persico, M</creatorcontrib><creatorcontrib>Bucci, M</creatorcontrib><creatorcontrib>Vellecco, V</creatorcontrib><creatorcontrib>Borbone, N</creatorcontrib><creatorcontrib>Morelli, E</creatorcontrib><creatorcontrib>Oliviero, G</creatorcontrib><creatorcontrib>Novellino, E</creatorcontrib><creatorcontrib>Piccialli, G</creatorcontrib><creatorcontrib>Cirino, G</creatorcontrib><creatorcontrib>Varra, M</creatorcontrib><creatorcontrib>Fattorusso, C</creatorcontrib><creatorcontrib>Mayol, L</creatorcontrib><title>Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue</title><title>Organic & biomolecular chemistry</title><addtitle>Org Biomol Chem</addtitle><description>Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.</description><subject>Antithrombins - chemical synthesis</subject><subject>Antithrombins - chemistry</subject><subject>Aptamers, Nucleotide - chemical synthesis</subject><subject>Aptamers, Nucleotide - chemistry</subject><subject>Circular Dichroism</subject><subject>G-Quadruplexes</subject><subject>Models, Molecular</subject><subject>Molecular Mimicry</subject><subject>Nucleosides - chemistry</subject><subject>Optical Rotation</subject><subject>Stereoisomerism</subject><subject>Thermodynamics</subject><subject>Thrombin - antagonists & inhibitors</subject><subject>Thrombin - chemistry</subject><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkT1PwzAQhi0EolBY-AHII0IqnGPna4TyKVXqUubIsS_FKLGL7SB15o-T0tKZ6e5ePXqGewm5YHDDgJe3SrgagIlSH5ATJvJ8AikvD_d7AiNyGsLHwJR5Jo7JKBFlAolgJ-R73scQpdXGLik2DaoYqLNU2mjiu3ddbYZDRfNl4pq6hnZOm8agpov7O6qNDBE9ug59oMrZKI3dmKSlbhWNkm27pqve4-BYq9YoanvVootGD5GVrVv2eEaOGtkGPN_NMXl7elxMXyaz-fPr9G42UTyBOKkTyLAQhRRFiqzQIBqNKFNUXGiUKuEyUUWOPK2zXBQi4zVXNaQSS64LyfmYXG29K-8-ewyx6kxQ2LbSoutDxdIMGBvexf6BCsgZB4ABvd6iyrsQPDbVyptO-nXFoNr0U03F_P63n4cBvtx5-7pDvUf_CuE_sxuNpw</recordid><startdate>20140728</startdate><enddate>20140728</enddate><creator>Scuotto, M</creator><creator>Persico, M</creator><creator>Bucci, M</creator><creator>Vellecco, V</creator><creator>Borbone, N</creator><creator>Morelli, E</creator><creator>Oliviero, G</creator><creator>Novellino, E</creator><creator>Piccialli, G</creator><creator>Cirino, G</creator><creator>Varra, M</creator><creator>Fattorusso, C</creator><creator>Mayol, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20140728</creationdate><title>Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue</title><author>Scuotto, M ; Persico, M ; Bucci, M ; Vellecco, V ; Borbone, N ; Morelli, E ; Oliviero, G ; Novellino, E ; Piccialli, G ; Cirino, G ; Varra, M ; Fattorusso, C ; Mayol, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antithrombins - chemical synthesis</topic><topic>Antithrombins - chemistry</topic><topic>Aptamers, Nucleotide - chemical synthesis</topic><topic>Aptamers, Nucleotide - chemistry</topic><topic>Circular Dichroism</topic><topic>G-Quadruplexes</topic><topic>Models, Molecular</topic><topic>Molecular Mimicry</topic><topic>Nucleosides - chemistry</topic><topic>Optical Rotation</topic><topic>Stereoisomerism</topic><topic>Thermodynamics</topic><topic>Thrombin - antagonists & inhibitors</topic><topic>Thrombin - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scuotto, M</creatorcontrib><creatorcontrib>Persico, M</creatorcontrib><creatorcontrib>Bucci, M</creatorcontrib><creatorcontrib>Vellecco, V</creatorcontrib><creatorcontrib>Borbone, N</creatorcontrib><creatorcontrib>Morelli, E</creatorcontrib><creatorcontrib>Oliviero, G</creatorcontrib><creatorcontrib>Novellino, E</creatorcontrib><creatorcontrib>Piccialli, G</creatorcontrib><creatorcontrib>Cirino, G</creatorcontrib><creatorcontrib>Varra, M</creatorcontrib><creatorcontrib>Fattorusso, C</creatorcontrib><creatorcontrib>Mayol, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scuotto, M</au><au>Persico, M</au><au>Bucci, M</au><au>Vellecco, V</au><au>Borbone, N</au><au>Morelli, E</au><au>Oliviero, G</au><au>Novellino, E</au><au>Piccialli, G</au><au>Cirino, G</au><au>Varra, M</au><au>Fattorusso, C</au><au>Mayol, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue</atitle><jtitle>Organic & biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2014-07-28</date><risdate>2014</risdate><volume>12</volume><issue>28</issue><spage>5235</spage><epage>5242</epage><pages>5235-5242</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.</abstract><cop>England</cop><pmid>24920241</pmid><doi>10.1039/c4ob00149d</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2014-07, Vol.12 (28), p.5235-5242 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1560115201 |
| source | Royal Society of Chemistry |
| subjects | Antithrombins - chemical synthesis Antithrombins - chemistry Aptamers, Nucleotide - chemical synthesis Aptamers, Nucleotide - chemistry Circular Dichroism G-Quadruplexes Models, Molecular Molecular Mimicry Nucleosides - chemistry Optical Rotation Stereoisomerism Thermodynamics Thrombin - antagonists & inhibitors Thrombin - chemistry |
| title | Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T21%3A15%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outstanding%20effects%20on%20antithrombin%20activity%20of%20modified%20TBA%20diastereomers%20containing%20an%20optically%20pure%20acyclic%20nucleotide%20analogue&rft.jtitle=Organic%20&%20biomolecular%20chemistry&rft.au=Scuotto,%20M&rft.date=2014-07-28&rft.volume=12&rft.issue=28&rft.spage=5235&rft.epage=5242&rft.pages=5235-5242&rft.issn=1477-0520&rft.eissn=1477-0539&rft_id=info:doi/10.1039/c4ob00149d&rft_dat=%3Cproquest_cross%3E1540713000%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c320t-b206e848a485e18d04fdeea5ec34deac23a2c87e35b6748463b3cb05ae93d8a33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1540713000&rft_id=info:pmid/24920241&rfr_iscdi=true |