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Noninvasive MRI measurement of the absolute cerebral blood volume-cerebral blood flow relationship during visual stimulation in healthy humans
Purpose The relationship between cerebral blood volume (CBV) and cerebral blood flow (CBF) underlies blood oxygenation level–dependent functional MRI signal. This study investigates the potential for improved characterization of the CBV‐CBF relationship in humans, and examines sex effects as well as...
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Published in: | Magnetic resonance in medicine 2014-09, Vol.72 (3), p.864-875 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Purpose
The relationship between cerebral blood volume (CBV) and cerebral blood flow (CBF) underlies blood oxygenation level–dependent functional MRI signal. This study investigates the potential for improved characterization of the CBV‐CBF relationship in humans, and examines sex effects as well as spatial variations in the CBV‐CBF relationship.
Methods
Healthy subjects were imaged noninvasively at rest and during visual stimulation, constituting the first MRI measurement of the absolute CBV‐CBF relationship in humans with complete coverage of the functional areas of interest.
Results
CBV and CBF estimates were consistent with the literature, and their relationship varied both spatially and with sex. In a region of interest with stimulus‐induced activation in CBV and CBF at a significance level of the P < 0.05, a power function fit resulted in CBV = 2.1 CBF0.32 across all subjects, CBV = 0.8 CBF0.51 in females and CBV = 4.4 CBF0.15 in males. Exponents decreased in both sexes as ROIs were expanded to include less significantly activated regions.
Conclusion
Consideration for potential sex‐related differences, as well as regional variations under a range of physiological states, may reconcile some of the variation across literature and advance our understanding of the underlying cerebrovascular physiology. Magn Reson Med 72:864–875, 2014. © 2013 Wiley Periodicals, Inc. |
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ISSN: | 0740-3194 1522-2594 |
DOI: | 10.1002/mrm.24984 |