Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats

Abstract Objective: Doxorubicin (DXR) is an anticancer drug used in the treatment of many human malignancies. However, its clinical use is limited because of several side effects like cardiotoxicity, nephrotoxicity and hepatotoxicity. In the present study, we investigated the protective efficacy of...

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Published in:Toxicology mechanisms and methods 2013-06, Vol.23 (5), p.337-345
Main Authors: Rashid, Summya, Ali, Nemat, Nafees, Sana, Ahmad, Shiekh Tanveer, Arjumand, Wani, Hasan, Syed Kazim, Sultana, Sarwat
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - toxicity
Chrysin
doxorubicin
Doxorubicin - toxicity
Flavonoids - pharmacology
hepatotoxicity
Kidney - drug effects
Liver - drug effects
Liver Function Tests
Male
Malondialdehyde - metabolism
nephrotoxicity
oxidative stress
Rats, Wistar
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Summary:Abstract Objective: Doxorubicin (DXR) is an anticancer drug used in the treatment of many human malignancies. However, its clinical use is limited because of several side effects like cardiotoxicity, nephrotoxicity and hepatotoxicity. In the present study, we investigated the protective efficacy of chrysin against DXR-induced oxidative stress, nephro- and hepatotoxicity in male Wistar rats using biochemical and histopathological approaches. Methodology: Wistar rats were subjected to concomitant pre- and post-phylactic oral treatment of chrysin (40 and 80 mg/kg b.wt.) against nephro- and hepatotoxicity induced by single i.p. injection of DXR (40 mg/kg b.wt). Nephrotoxicity and hepatotoxicity were assessed by measuring the level of serum creatinine, BUN, AST, ALT and LDH. The level of antioxidant armory of kidney and liver tissue was also measured. Key findings: Treatment with chrysin significantly decreased the levels of serum toxicity markers and additionally elevated antioxidant defense enzyme levels. Histopathological changes further confirmed the biochemical results showing that DXR caused significant structural damage to kidney and liver tissue architecture which were reversed with chrysin. Conclusion: The results suggest that chrysin attenuated nephro and hepatic damage induced by DXR.
ISSN:1537-6516
1537-6524
DOI:10.3109/15376516.2012.759306