Loading…

Thionium-Based One-Pot Construction of Homo-/Heterodimeric Pyrroloindoline from Tryptamine

We report a one-pot procedure for forming a dimeric pyrroloindoline framework with a thionium reagent. The cyclization of tryptamine with DMSO and Tf2O, followed by substitution with indole derivatives, produced racemic 3a-indolylpyrroloindolines. The method enables rapid access to heterodimeric pyr...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2014-07, Vol.16 (14), p.3613-3615
Main Authors: Tayu, Masanori, Higuchi, Kazuhiro, Ishizaki, Takako, Kawasaki, Tomomi
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a one-pot procedure for forming a dimeric pyrroloindoline framework with a thionium reagent. The cyclization of tryptamine with DMSO and Tf2O, followed by substitution with indole derivatives, produced racemic 3a-indolylpyrroloindolines. The method enables rapid access to heterodimeric pyrroloindolines as well as to homodimeric pyrroloindolines.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol5012373