Evidence of inappropriate cardiovascular risk assessment in middle-age women based on recommended cut-points for waist circumference

Abstract Background and aims Diverse waist circumference thresholds for assessment of metabolic and cardiovascular risk in Caucasians are recommended by different health professional organizations. We aimed to determine optimal sex-specific thresholds for anthropometric measures showing the stronges...

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Bibliographic Details
Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-10, Vol.24 (10), p.1112-1119
Main Authors: Florath, I, Brandt, S, Weck, M.N, Moss, A, Gottmann, P, Rothenbacher, D, Wabitsch, M, Brenner, H
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Assessment, risk
Blood Glucose - metabolism
Blood Pressure
BMI
Body Composition
Body Mass Index
Cardiovascular
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Cohort Studies
Cut-points
Female
Follow-Up Studies
Germany
Humans
Insulin - blood
Male
Middle Aged
Obesity, Abdominal - epidemiology
Obesity, Abdominal - prevention & control
Prevalence
Risk Assessment
Risk Factors
Syndrome, metabolic cardiovascular
Waist Circumference
Waist-Height Ratio
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Summary:Abstract Background and aims Diverse waist circumference thresholds for assessment of metabolic and cardiovascular risk in Caucasians are recommended by different health professional organizations. We aimed to determine optimal sex-specific thresholds for anthropometric measures showing the strongest association with cardiovascular risk factors in a cohort of middle-aged Germans. Methods and results Statistical analyses are based on data from 426 mothers and 267 fathers of participants of the Ulm Birth Cohort Study undergoing a clinical follow-up examination in 2008 (median age 41 years) using logistic regression analyses. The prevalence of many cardiometabolic risk factors was significantly higher in men than in women; hypertension: 45%/17% ( p   0.72: 35%/9% ( 25: 64%/35%). The prediction of cardiometabolic risk factors by waist circumference and waist-to-height ratio did not outperform the prediction by BMI. In contrast to BMI, waist circumference was correlated with body height independent of sex. Conclusion Currently proposed thresholds for waist circumference spuriously overestimate the cardiovascular risk in women, but not in men in a German population.
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2014.04.005