Cardiac Magnetic Resonance Performs Better in the Detection of Functionally Significant Coronary Artery Stenosis Compared to Single-Photon Emission Computed Tomography and Dobutamine Stress Echocardiography

• Published in: Circulation Journal 2014/09/25, Vol.78(10), pp.2468-2476
• Main Authors: Kamiya, Kiwamu, Sakakibara, Mamoru, Asakawa, Naoya, Yamada, Shiro, Yoshitani, Takashi, Iwano, Hiroyuki, Komatsu, Hiroshi, Naya, Masanao, Chiba, Satoru, Yamada, Satoshi, Manabe, Osamu, Kikuchi, Yasuka, Oyama-Manabe, Noriko, Oba, Koji, Tsutsui, Hiroyuki
• Format: Article
• Language: English
• Subjects: Aged; Cardiac magnetic resonance; Coronary Artery Disease - diagnosis; Coronary Stenosis - diagnosis; Dobutamine stress echocardiography; Echocardiography, Stress - methods; Female; Fractional flow reserve; Humans; Ischemia; Magnetic Resonance Angiography - methods; Male; Middle Aged; Prospective Studies; Single-photon emission computed tomography; Tomography, Emission-Computed, Single-Photon - methods
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.CJ-13-1454

Background:Fractional flow reserve (FFR) measured on catheterization is now widely used for the diagnosis of functional myocardial ischemia in patients with coronary artery disease (CAD). FFR, however, is invasive and carries potential procedural complications. Therefore, the aim of this study was to compare the diagnostic capability in functionally significant stenosis identified on FFR, between cardiac magnetic resonance myocardial perfusion imaging (CMR-MPI), single-photon emission computed tomography MPI (SPECT-MPI), and dobutamine stress echocardiography (DSE) in patients with CAD.Methods and Results:A total of 25 patients who had at least 1 angiographic stenosis ≥50% on coronary angiography was studied. CMR-MPI, SPECT-MPI and DSE were done before FFR measurement. FFR was measured in all 3 major epicardial coronary arteries. Out of 71 vascular territories excluding 4 territories due to inadequate imaging, 29 (41%) had FFR