Treatment with human chorionic gonadotrophin before ovulation increases progestin concentration in early equine pregnancies

•We evaluate treatments for prevention of early pregnancy loss in mares.•We analyse influences of hCG treatment on luteal function in early pregnant mares.•Induction of ovulation with hCG increased progestin concentration.•Treatment with hCG on day 5 after ovulation did not affect progestin secretio...

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Bibliographic Details
Published in:Animal reproduction science 2014-10, Vol.149 (3-4), p.187-193
Main Authors: Köhne, Martin, Kuhl, Juliane, Ille, Natascha, Erber, Regina, Aurich, Christine
Format: Article
Language:English
Subjects:
Animals
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - pharmacology
Corpus luteum
Drug Administration Schedule
Endometrium - drug effects
Endometrium - physiology
Female
hCG
Horse
Horses - embryology
Horses - physiology
Ovulation - physiology
Ovulation Induction - veterinary
Pregnancy
Pregnancy, Animal - drug effects
Progestin
Progestins - metabolism
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Summary:•We evaluate treatments for prevention of early pregnancy loss in mares.•We analyse influences of hCG treatment on luteal function in early pregnant mares.•Induction of ovulation with hCG increased progestin concentration.•Treatment with hCG on day 5 after ovulation did not affect progestin secretion.•Treatment of mares with hCG for induction of ovulation may support early pregnancy. For prevention of early conceptus loss in the horse, treatment with progestins has become common practice. In cattle, treatment with human chorionic gonadotrophin (hCG) during the early postovulatory phase stimulates endogenous progesterone synthesis, which is an important factor for maintenance of early pregnancy via stimulation of endometrial function and conceptus development. In the present study we have therefore investigated the influence of treatment with hCG either for induction of ovulation or during the early luteal phase on plasma progestin concentrations, size of the corpus luteum and size of the conceptus in early pregnant mares. We hypothesized that hCG treatment stimulates progestin secretion and conceptus development. In Experiment 1, induction of ovulation with hCG (1500IU i.v.; n=14) significantly increased progestin concentration between days 5 and 15 after ovulation compared to untreated controls (n=28; p
ISSN:0378-4320
1873-2232
DOI:10.1016/j.anireprosci.2014.07.002