Changes in Muscle Strength in Patients With Statin Myalgia

Statins can produce myalgia or muscle pain, which may affect medication adherence. We measured the effects of statins on muscle strength in patients with previous statin myalgia. Leg isokinetic extension average power at 60° per second (−8.8 ± 10.5N-M, p = 0.02) and average peak torque at 60° per se...

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Bibliographic Details
Published in:The American journal of cardiology 2014-10, Vol.114 (8), p.1215-1216
Main Authors: Panza, Gregory A., MS, Taylor, Beth A., PhD, Roman, William, BS, Thompson, Paul D., MD
Format: Article
Language:English
Subjects:
Aged
Cardiovascular
Connecticut - epidemiology
Exercise Test
Female
Follow-Up Studies
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Hypercholesterolemia - drug therapy
Inventory
Male
Metabolism
Middle Aged
Muscle Strength - drug effects
Muscle Strength - physiology
Muscle Strength Dynamometer
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiopathology
Myalgia - chemically induced
Myalgia - epidemiology
Myalgia - physiopathology
Patients
Prevalence
Prognosis
Risk Factors
Statins
Variables
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Summary:Statins can produce myalgia or muscle pain, which may affect medication adherence. We measured the effects of statins on muscle strength in patients with previous statin myalgia. Leg isokinetic extension average power at 60° per second (−8.8 ± 10.5N-M, p = 0.02) and average peak torque at 60° per second (−14.0 ± 19.7N-M, p = 0.04) decreased slightly with statin use, but 8 of 10 other variables for leg strength did not change (all p >0.13). Handgrip, muscle pain, respiratory exchange ratio, and daily activity also did not change (all p >0.09). In conclusion, statin myalgia is not associated with reduced muscle strength or muscle performance.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2014.07.042