The effects of exercise on oxidative stress (TBARS) and BDNF in severely depressed inpatients

Exercise can be an effective treatment for depression. Although the efficacy of exercise is well established, little is known concerning the biological changes associated with the antidepressant effects of exercise. A randomized, controlled trial was conducted to evaluate the effects of adding exerc...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2014-10, Vol.264 (7), p.605-613
Main Authors: Schuch, Felipe Barreto, Vasconcelos-Moreno, Mirela Paiva, Borowsky, Carolina, Zimmermann, Ana Beatriz, Wollenhaupt-Aguiar, Bianca, Ferrari, Pamela, de Almeida Fleck, Marcelo Pio
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Antidepressive Agents - therapeutic use
Brain-Derived Neurotrophic Factor - blood
Depression - drug therapy
Depression - metabolism
Depression - physiopathology
Depression - rehabilitation
Enzyme-Linked Immunosorbent Assay
Exercise - physiology
Exercise Therapy - methods
Female
Heart Rate
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosciences
Original Paper
Oxidative Stress - physiology
Oxygen Consumption
Psychiatric Status Rating Scales
Psychiatry
Retrospective Studies
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Exercise can be an effective treatment for depression. Although the efficacy of exercise is well established, little is known concerning the biological changes associated with the antidepressant effects of exercise. A randomized, controlled trial was conducted to evaluate the effects of adding exercise to the usual treatment on the thiobarbituric acid-reactive substances (TBARS) and brain-derived neurotrophic factor (BDNF) serum levels of severely depressed inpatients. Twenty-six participants were randomized to an exercise group ( n  = 15, exercise + treatment as usual) or a control group ( n  = 11, treatment as usual). The participants in the exercise group completed a targeted dose of 16.5 kcal/kg/week of aerobic exercise, three times per week, throughout their hospitalizations. The control group did not exercise during their hospitalizations. The mean hospitalization length was of 21.63 (4.5) × 23.82 (5.7) days for exercise and control groups, respectively. The exercise group performed a median of nine sessions. After adjusting for previous tobacco use, a significant group × time interaction was found for TBARS serum levels ( p  = 0.02). A post hoc Bonferroni test revealed differences between the exercise and control groups at discharge. A significant time effect ( p  
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-014-0489-5