Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients

A deletion of two genes from the late cornified envelope (LCE), LCE3B and LCE3C within epidermal differentiation complex on chromosome 1 was shown to be associated with both psoriasis and psoriatic arthritis (PsA) in several populations. To assess whether this deletion may contribute to the genetic...

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Bibliographic Details
Published in:Molecular biology reports 2014-06, Vol.41 (6), p.4141-4146
Main Authors: Chiraz, Bouchlaka Souissi, Myriam, Ammar, Ines, Zarra, Catherine, Jordan, Fatma, Bouazizi, Ilhem, Cheour, Raoudha, Tekaya, Hela, Zeglaoui, Hela, Fourati, Elyes, Bouajina, Nejib, Doss, Cindy, Helms, Amel, Elgaaied, Slaheddine, Sellami
Format: Article
Language:English
Subjects:
Adult
Animal Anatomy
Animal Biochemistry
Arthritis
Arthritis, Psoriatic - genetics
Arthritis, Psoriatic - pathology
Biomedical and Life Sciences
Chromosome Deletion
chromosomes
Cornified Envelope Proline-Rich Proteins - genetics
Female
Gene Deletion
genes
Genetic Association Studies
Genetic markers
Genetic Predisposition to Disease
Genetics
Histology
HLA-C Antigens - genetics
Humans
Life Sciences
Male
Middle Aged
Morphology
patients
Polymorphism
Polymorphism, Single Nucleotide
Proteins - genetics
Psoriasis
risk factors
single nucleotide polymorphism
Tunisia
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Summary:A deletion of two genes from the late cornified envelope (LCE), LCE3B and LCE3C within epidermal differentiation complex on chromosome 1 was shown to be associated with both psoriasis and psoriatic arthritis (PsA) in several populations. To assess whether this deletion may contribute to the genetic predisposition to PsA in Tunisia, a total of 73 patients with PsA and 120 healthy matched controls were screened for the deletion, LCE3C_LCE3B-del, and its tag SNP, rs4112788. We also evaluated a possible relationship between PSORS1 and LCE3C_LCE3B-del through genotyping two proxy markers to HLA-C (rs12191877 and rs2073048). Our results did not provide evidence for association between the LCE3C_LCE3B-del nor the rs4112788 and the PsA. Similarly, no significant epistatic effect was observed. Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients supporting the current perception that different genetic risk factors contribute to skin and joint disease. However, these results need to be confirmed by additional large-scale studies of Tunisian PsA patients and controls.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-014-3285-4