Role of Electrostatics in the Sequence-Selective Reaction of Charged Alkylating Agents with DNA

To determine if the controlled positioning of cationic groups could be used to modulate the electrostatic potential in the major groove, MNU was reacted with DNA containing 5-(6-amino-hexyl)-2'-deoxycytidine (zwitterionic dC) residues. We report herein that the incorporation of a zwitterionic d...

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Bibliographic Details
Published in:Journal of the American Chemical Society 1995-10, Vol.117 (40), p.10135-10136
Main Authors: Liang, Gangning, Encell, Lance, Nelson, Marek G, Switzer, Christopher, Shuker, David E. G, Gold, Barry
Format: Article
Language:English
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Summary:To determine if the controlled positioning of cationic groups could be used to modulate the electrostatic potential in the major groove, MNU was reacted with DNA containing 5-(6-amino-hexyl)-2'-deoxycytidine (zwitterionic dC) residues. We report herein that the incorporation of a zwitterionic dC allows regiospecific inhibition of N7-alkylation of G in duplex DNA by MNU.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00145a034