Physiological measurements after ovariohysterectomy in dogs: what's normal?

Twenty-two pet dogs presented to the North Carolina State University Veterinary Teaching Hospital for elective ovariohysterectomy were treated with oxymorphone 2.5 mg m −2 (Surgery-O group, n = 11) or placebo (Surgery-P group, n = 11) immediately before the induction of anesthesia and 6, 12 and 18 h...

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Bibliographic Details
Published in:Applied animal behaviour science 1997, Vol.51 (1), p.101-109
Main Authors: Hansen, Bernard D., Hardie, Elizabeth M., Carroll, Gwendolyn S.
Format: Article
Language:English
Subjects:
CHIEN
Cortisol
DOGS
DOLOR
DOULEUR
DRUGS
ESTRES
GLUCOCORTICOIDE
GLUCOCORTICOIDES
GLUCOCORTICOIDS
MEDICAMENT
MEDICAMENTOS
OVARIECTOMIA
OVARIECTOMIE
OVARIECTOMY
Ovariohysterectomy
Oxymorphone
PAIN
PERRO
STRESS
Surgery
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Summary:Twenty-two pet dogs presented to the North Carolina State University Veterinary Teaching Hospital for elective ovariohysterectomy were treated with oxymorphone 2.5 mg m −2 (Surgery-O group, n = 11) or placebo (Surgery-P group, n = 11) immediately before the induction of anesthesia and 6, 12 and 18 h later. Seventeen random source dogs assigned to a control group that underwent anesthesia alone for 2 h received identical treatment with oxymorphone (Control-O group, n = 9) or placebo (Control-P group, n = 8). The heart rate, respiratory rate, temperature and blood pressure were measured preoperatively, at the time of skin incision (or 1 h after anesthetic induction of controls), at extubation and at hours 1, 3, 6, 12 and 24 after extubation. Plasma cortisol concentration was measured preoperatively, at extubation and at hours 3, 6 and 12. Treatment with oxymorphone reduced the heart rate and body temperature in both the Surgery-O and Control-O groups, but no differences in physical findings suggesting an analgesic effect of the drug were identified. Elevated plasma cortisol concentrations were found at hours 3 and 6 in both surgery groups, whereas the plasma cortisol concentration in the control groups did not change. The plasma cortisol concentration was reduced in the Surgery-O group compared to the Surgery-P group at hours 3–12, suggesting an analgesic effect of the drug. We conclude that routinely monitored physiological signs are not sensitive indicators of a stress response to ovariohysterectomy, or of an analgesic effect of oxymorphone.
ISSN:0168-1591
1872-9045
DOI:10.1016/S0168-1591(96)01079-9