Mediation of serotonin-induced branchial vasoconstriction by a cholinergic and muscarinic response in vivo in European eel Anguilla anguilla

The intravenous administration of serotonin (5-hydroxytryptamine: 5-HT) induced a significant branchial vasoconstriction in vivo in European eel. This effect is blocked either by methysergide or atropine treatment suggesting a mediation of the serotonin-induced vasoconstriction by both methysergide-...

Full description

Saved in:
Bibliographic Details
Published in:Fish physiology and biochemistry 1997-01, Vol.16 (1), p.85-92
Main Author: Janvier, J-J
Format: Article
Language:English
Subjects:
Anguilla anguilla
Freshwater
Marine
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The intravenous administration of serotonin (5-hydroxytryptamine: 5-HT) induced a significant branchial vasoconstriction in vivo in European eel. This effect is blocked either by methysergide or atropine treatment suggesting a mediation of the serotonin-induced vasoconstriction by both methysergide-sensitive serotonergic receptors and by cholinergic muscarinic receptors of the branchial vasculature. The intravenous administration of 5-HT caused an increase (250%) in ventilatory water flow (V sub(w)) together with a rise (250%) in partial pressure of oxygen in arterial blood (PaO sub(2)). Under imposed steady ventilatory water flow in curarized eels, serotonin induced a significant increase in PaO sub(2) which i) appeared at the time of branchial vasoconstriction, ii) was blocked by methysergide treatment, and iii) was not related to an elevation of plasma catecholamine levels. These results suggest that 5-HT causes a constriction of branchial vasculature in a site where serotonergic and cholinergic receptors are both present. The localization of serotonin-induced branchial vasoconstriction is discussed.
ISSN:0920-1742
DOI:10.1007/BF00004543