Human phagocytic cells as oxygen metabolite scavengers

Human neutrophils or monocytes decreased hydrogen peroxide (H2O2) concentrations in vitro. Neutrophils or monocytes decreased H2O2 concentrations as well as human erythrocytes. Treatment with aminotriazole or azide decreased both phagocyte and erythrocyte catalase activity and the ability of each ce...

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Bibliographic Details
Published in:Inflammation 1990-10, Vol.14 (5), p.613-619
Main Authors: BERGER, E. M, BEEHLER, C. J, HARADA, R. N, REPINE, J. E
Format: Article
Language:English
Subjects:
Amitrole - pharmacology
Azides - pharmacology
Biological and medical sciences
Catalase - metabolism
Cell metabolism, cell oxidation
Cell physiology
Erythrocytes - metabolism
Free Radicals
Fundamental and applied biological sciences. Psychology
Humans
Hydrogen Peroxide - metabolism
Leukocytes, Mononuclear - drug effects
Leukocytes, Mononuclear - metabolism
Molecular and cellular biology
Neutrophils - metabolism
Oxidation-Reduction
Oxygen - metabolism
Sodium Azide
Tetradecanoylphorbol Acetate - pharmacology
Zymosan - pharmacology
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Summary:Human neutrophils or monocytes decreased hydrogen peroxide (H2O2) concentrations in vitro. Neutrophils or monocytes decreased H2O2 concentrations as well as human erythrocytes. Treatment with aminotriazole or azide decreased both phagocyte and erythrocyte catalase activity and the ability of each cell to decrease H2O2 concentrations in vitro. Prestimulation of phagocytic cells with phorbol myristate acetate (PMA) or opsonized zymosan decreased neither their catalase activity nor their ability to decrease H2O2 concentrations. The results suggest that unstimulated or stimulated phagocytic cells can scavenge H2O2 and may potentially decrease H2O2-mediated tissue injury. The H2O2 scavenging potential of phagocytic cells is due at least partially to their catalase activity.
ISSN:0360-3997
1573-2576