World Association for the Advancement of Veterinary Parasitology (WAAVP): Guideline for the evaluation of drug efficacy against non-coccidial gastrointestinal protozoa in livestock and companion animals

The current guideline was written to aid in the design, implementation and interpretation of studies for the assessment of drug efficacy against non-coccidial gastrointestinal protozoan parasites, with Giardia spp. as the leading example. The information provided in this guideline deals with aspects...

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Bibliographic Details
Published in:Veterinary parasitology 2014-08, Vol.204 (3-4), p.81-86
Main Authors: Geurden, T, Olson, M E, O'Handley, R M, Schetters, T, Bowman, D, Vercruysse, J
Format: Article
Language:English
Subjects:
Animals
Dose-Response Relationship, Drug
Gastrointestinal Diseases - drug therapy
Gastrointestinal Diseases - veterinary
Giardiasis - drug therapy
Giardiasis - veterinary
Livestock - parasitology
Pets - parasitology
Protozoan Infections, Animal - drug therapy
Research Design
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Summary:The current guideline was written to aid in the design, implementation and interpretation of studies for the assessment of drug efficacy against non-coccidial gastrointestinal protozoan parasites, with Giardia spp. as the leading example. The information provided in this guideline deals with aspects of how to conduct controlled studies using experimental infection models (dose determination and dose confirmation) and efficacy studies in commercial facilities (field effectiveness studies). Furthermore, the selection of suitable animals, housing, infection procedure, choice of diagnostic technique and data analysis are discussed. This guideline is intended to assist investigators in conducting specific studies, to provide specific information for registration authorities involved in the decision-making process, to assist in the approval and registration of new drugs and to facilitate the worldwide adoption of uniform procedures. The primary parameter for drug efficacy is the reduction in either parasite excretion or parasite counts and a minimum efficacy of 90% is required against non-coccidial gastrointestinal protozoa. A supporting efficacy parameter is a significant difference in the proportion of infected animals between treated and non-treated groups. Persistent efficacy is considered as an additional claim to therapeutic efficacy.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2014.02.050