Eicosapentaenoic acid and epidermal growth factor modulation of human breast cancer cell adhesion

Cancer cell adhesion to the subendothelial extracellular matrix (ECM) is an important step in metastasis formation. The effect of epidermal growth factor (EGF) and eicosapentaenoic acid (EPA) on adhesion of the highly metastatic MDA-MB-231 human breast cancer cell line to ECM components was examined...

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Bibliographic Details
Published in:Cancer letters 1997-09, Vol.118 (1), p.95-100
Main Authors: German, Nina S., Johanning, Gary L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Breast cancer cell lines
Breast Neoplasms
Cell adhesion
Cell Adhesion - drug effects
Collagen
Dissemination
Dose-Response Relationship, Drug
Drug Combinations
Drug Interactions
Eicosapentaenoic acid
Eicosapentaenoic Acid - pharmacology
Epidermal growth factor
Epidermal Growth Factor - pharmacology
Extracellular Matrix
Extracellular Matrix Proteins - physiology
Female
Fibronectins
Humans
Laminin
Medical sciences
Metastasis
Neoplasm Metastasis
Proteoglycans
Tumor cell
Tumor Cells, Cultured
Tumors
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Summary:Cancer cell adhesion to the subendothelial extracellular matrix (ECM) is an important step in metastasis formation. The effect of epidermal growth factor (EGF) and eicosapentaenoic acid (EPA) on adhesion of the highly metastatic MDA-MB-231 human breast cancer cell line to ECM components was examined in the present study. MDA-MB-231 cells exhibited a dose-dependent decrease in adhesion to Matrigel when treated with EGF. EGF and EPA, alone or in combination, decreased adhesion to Matrigel, fibronectin and type IV collagen. These results suggest that decreased adhesion to ECM substrates by combined EPA and EGF treatment may be the result of a common post-receptor signaling pathway.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)00236-X