Glucose‐6‐phosphate dehydrogenase deficiency: an unusual cause of acute jaundice after paracetamol overdose

Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is the commonest human enzyme defect causing haemolytic anaemia after exposure to specific triggers. Paracetamol‐induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children. We report the first case (to the best of...

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Bibliographic Details
Published in:European journal of haematology 2014-11, Vol.93 (5), p.446-448
Main Authors: Phillpotts, Simon, Tash, Elliot, Sen, Sambit
Format: Article
Language:English
Subjects:
Acetaminophen - adverse effects
Acute Disease
Adult
anaemia
Antipyretics - adverse effects
Drug Overdose - metabolism
Drug Overdose - physiopathology
Female
Glucosephosphate Dehydrogenase Deficiency - chemically induced
Glucosephosphate Dehydrogenase Deficiency - complications
Glucosephosphate Dehydrogenase Deficiency - metabolism
Glucosephosphate Dehydrogenase Deficiency - physiopathology
Glucose‐6‐phosphate deficiency
Glucose‐6‐phosphate dehydrogenase
haemolysis
Humans
Jaundice - chemically induced
Jaundice - complications
Jaundice - metabolism
Jaundice - physiopathology
paracetamol
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Summary:Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is the commonest human enzyme defect causing haemolytic anaemia after exposure to specific triggers. Paracetamol‐induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children. We report the first case (to the best of our knowledge) of acute jaundice without overt clinical features of a haemolytic crisis, in an otherwise healthy adult female following paracetamol overdose, due to previously undiagnosed G6PD deficiency. It is important that clinicians consider this condition when a patient presents following a paracetamol overdose with significant and disproportionate jaundice, without transaminitis or coagulopathy.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.12330