High intratumoral macrophage content is an adverse prognostic feature in anaplastic large cell lymphoma

Aims Macrophage infiltration has been associated with prognosis in several cancers, including lymphoma, but has not been assessed systematically in anaplastic large cell lymphoma (ALCL). The aim of the study was to correlate expression of the macrophage‐associated antigens CD68 and CD163 with pre‐th...

Full description

Saved in:
Bibliographic Details
Published in:Histopathology 2014-10, Vol.65 (4), p.490-500
Main Authors: Pedersen, Martin B, Danielsen, Allan V, Hamilton-Dutoit, Stephen J, Bendix, Knud, Nørgaard, Peter, Møller, Michael B, Steiniche, Torben, d'Amore, Francesco
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
anaplastic large cell lymphoma
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
CD163
CD68
Disease-Free Survival
Female
Humans
immunohistochemistry
Lymphoma, Large-Cell, Anaplastic - diagnosis
Lymphoma, Large-Cell, Anaplastic - metabolism
macrophages
Macrophages - metabolism
Male
Middle Aged
Prognosis
Receptor Protein-Tyrosine Kinases - analysis
Receptors, Cell Surface - metabolism
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims Macrophage infiltration has been associated with prognosis in several cancers, including lymphoma, but has not been assessed systematically in anaplastic large cell lymphoma (ALCL). The aim of the study was to correlate expression of the macrophage‐associated antigens CD68 and CD163 with pre‐therapeutic parameters and outcome in a cohort of treatment‐naive ALCL patients. Methods and results Pre‐therapeutic tumour specimens from 52 patients with ALCL were included in a tissue microarray. The intratumoral macrophage content was assessed by immunohistochemical staining for CD68 and CD163, and quantified using digital image analysis. Anaplastic lymphoma kinase (ALK)‐positive patients were significantly younger and had a favourable outcome compared with ALK‐negative ALCL patients (median age: 42 versus 59 years; P = 0.008). However, ALK expression was not a significant predictor when adjusting for age. Although classical risk factors were distributed evenly between the compared groups, high intratumoral content of CD68 and/or CD163 correlated with poor outcome, in both univariate and multivariate analyses. High intratumoral CD163 content showed the strongest adverse association with both overall and progression‐free survival in ALK‐negative patients (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12407